Radysh, V.V., Maksymiv, D.V., Makarenko, A.N. (2006). [Complex influence of pharmacological agents on degenerative processes in brain of Drosophila melanogaster mutants] Eksp. Klin. Farmakol. 69(5): 16--19.
FlyBase ID
FBrf0192027
Publication Type
Research paper
Abstract
A scheme of complex administration of drugs in the order neuroprotector + neuroactivator + neuroretarder for the treatment of neurodegenerative processes in the brain has been elaborated and tested on a model object representing neurodegenerative mutants of Drosophila melanogaster. The appearance of changes in the brain was delayed when drugs were used separately: donepezil hydrochloride (arisept), 10 - 11 days, epinephrine and nimodipine, 1 - 2 days. The treatment of flies with the same drugs in the order arisept + epinephrine + nimodipine leads to the complete regeneration of D. melanogaster brain tissue to within 15 days of imago life.
