Schlesinger, A., Shilo, B.Z. (2005). ER retention of signaling modules.  Dev. Cell 8(2): 136--137.

FBrf0195907

Review

A novel strategy for controlling developmental signaling pathways, which uses specific ER retention mechanisms, has emerged from several recent studies. A paper by Yamamoto et al. (2005) identifies a new protein termed Shisa that inhibits both Wnt- and FGF-signaling pathways during Xenopus gastrulation by mediating ER retention of the Wnt receptor Frizzled and the FGF receptor.