FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Gene: Dmel\boca
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General Information
Symbol
Dmel\boca
Species
D. melanogaster
Name
boca
Annotation Symbol
CG30498
Feature Type
protein_coding_gene
FlyBase ID
FBgn0004132
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Summary
boca (boca) encodes an endoplasmic reticulum protein that is evolutionarily conserved. It is required for the intracellular trafficking of members of the low-density lipoprotein family of receptors, including the one encoded by arr. As such, boca mutants are compromised for a number of pathways including Wingless signaling. [Date last reviewed: 2019-03-21] (FlyBase Gene Snapshot)
All Summaries
Also Known As

l(2)43Ea

Key Links
Genomic Location
Cytogenetic map
43D7-43D7
Sequence location
Recombination map
2-56
RefSeq locus
NT_033778 REGION:7565873..7566738
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (8 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport
inferred from expression pattern
(Culi and Mann, 2003)
involved_in protein folding
inferred from mutant phenotype
(Culi and Mann, 2003)
involved_in protein targeting to membrane
inferred from mutant phenotype
(Culi and Mann, 2003)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in protein folding
inferred from electronic annotation with InterPro:IPR019330
(InterPro Project Members, 2004-)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
located_in apical part of cell
inferred from direct assay
(Culi and Mann, 2003)
located_in cytoplasm
inferred from direct assay
(Culi and Mann, 2003)
located_in endomembrane system
inferred from high throughput direct assay
(Tan et al., 2009)
located_in endoplasmic reticulum lumen
inferred from direct assay
(Culi and Mann, 2003)
located_in endoplasmic reticulum
inferred from direct assay
(Abrams et al., 2013)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the MESD family. (Q8T9B6)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
boca (boca) encodes an endoplasmic reticulum protein that is evolutionarily conserved. It is required for the intracellular trafficking of members of the low-density lipoprotein family of receptors, including the one encoded by arr. As such, boca mutants are compromised for a number of pathways including Wingless signaling. [Date last reviewed: 2019-03-21]
Protein Function (UniProtKB)
Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wg pathway, since some LDLRs are coreceptors for the canonical Wnt pathway.
(UniProt, Q8T9B6)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\boca for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q8T9B6)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
PDB - An information portal to biological macromolecular structures
Comments on Gene Model

Gene model reviewed during 5.42

Gene model reviewed during 5.48

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
boca-RA
FBtr0088953
NM_165541
704
180
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
boca-PA
FBpp0088027
21.0
180
4.53
Q8T9B6
NP_724578
AAF59229
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Monomer (By similarity). Interacts with Arrow and Yolkless.

(UniProt, Q8T9B6)
Domain

The LDLR maturation activity resides in the N- and C-terminal unstructured regions.

(UniProt, Q8T9B6)
Crossreferences
InterPro - A database of protein families, domains and functional sites
PDB - An information portal to biological macromolecular structures
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\boca using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.25

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
organism | ubiquitous
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 15
embryonic/larval salivary gland body
(Abrams et al., 2013)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in apical part of cell
inferred from direct assay
(Culi and Mann, 2003)
located_in cytoplasm
inferred from direct assay
(Culi and Mann, 2003)
located_in endomembrane system
inferred from high throughput direct assay
(Tan et al., 2009)
located_in endoplasmic reticulum lumen
inferred from direct assay
(Culi and Mann, 2003)
located_in endoplasmic reticulum
inferred from direct assay
(Abrams et al., 2013)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\boca in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 3 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of boca
Transgenic constructs containing regulatory region of boca
Aberrations (Deficiencies and Duplications) ( 42 )
Inferred from experimentation ( 42 )
Gene disrupted in
Df(2R)cn-S5
(Heitzler et al., 1993)
Df(2R)cn-S6
(Heitzler et al., 1993)
Df(2R)Drlrv5
(Heitzler et al., 1993)
Df(2R)Drlrv7
(Heitzler et al., 1993)
Df(2R)Drlrv15
(Culi and Mann, 2003, Heitzler et al., 1993)
Df(2R)Drlrv18
(Heitzler et al., 1993)
Df(2R)Drlrv20
(Heitzler et al., 1993)
Df(2R)Drlrv21
(Heitzler et al., 1993)
Df(2R)Drlrv24
(Heitzler et al., 1993)
Df(2R)Drlrv26
(Heitzler et al., 1993)
Df(2R)Drlrv30
(Heitzler et al., 1993)
Df(2R)Exel6052
(Ryder, 2004.4.26)
Df(2R)Exel6053
(Ryder, 2004.4.26)
Df(2R)k08815
(Kahsai and Cook, 2018)
Df(2R)NCX9
(Heitzler et al., 1993)
Df(2R)NCX11
(Heitzler et al., 1993)
Df(2R)NCX13
(Eeken et al., 2001)
Df(2R)sple-D3
(Roote, 1996.8, Heitzler et al., 1993)
Df(2R)sple-N3
(Heitzler et al., 1993)
Df(2R)ST1
(Eeken et al., 2001)
Gene not disrupted in
Df(2R)cn-S8
(Roote, 1996.8, Heitzler et al., 1993)
Df(2R)cos-2
(Heitzler et al., 1993)
Df(2R)cos-3
(Heitzler et al., 1993)
Df(2R)Drlrv3
(Heitzler et al., 1993)
Df(2R)Drlrv17
(Heitzler et al., 1993)
Df(2R)Drlrv22
(Heitzler et al., 1993)
Df(2R)Drlrv25
(Heitzler et al., 1993)
Df(2R)Drlrv28
(Heitzler et al., 1993)
Df(2R)DX1
(Heitzler et al., 1993)
Df(2R)DX14
(Heitzler et al., 1993)
Df(2R)EW60
(Heitzler et al., 1993)
Df(2R)H23
(Heitzler et al., 1993)
Df(2R)nap2
(Heitzler et al., 1993)
Df(2R)NCX5
(Heitzler et al., 1993)
Df(2R)NCX8
(Eeken et al., 2001, Heitzler et al., 1993)
Df(2R)NCX10
(Heitzler et al., 1993)
Df(2R)pk-N5
(Heitzler et al., 1993)
Df(2R)pwn5
(Heitzler et al., 1993)
Df(2R)sple-D1
(Heitzler et al., 1993)
Df(2R)sple-D2
(Heitzler et al., 1993)
Df(2R)sple-J1
(Heitzler et al., 1993)
Df(2R)sple-J2
(Heitzler et al., 1993)
Inferred from location ( 5 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (1)
Hsap\MESD
14 of 14
Yes
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (1)
Rnor\Mesd
14 of 14
Yes
Yes
Mus musculus (laboratory mouse) (1)
Mmus\Mesd
13 of 14
Yes
Yes
Xenopus tropicalis (Western clawed frog) (3)
Xtro\mesd
7 of 13
Yes
Yes
Xtro\trio
6 of 13
No
No
Xtro\lpar6
1 of 13
No
No
Danio rerio (Zebrafish) (1)
Drer\mesd
13 of 14
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\bmy-1
14 of 14
Yes
Yes
Cele\srg-69
2 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP005081
12 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:boca. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    MESD; mesoderm development LRP chaperone
    model of  osteogenesis imperfecta type 20
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    MESD; mesoderm development LRP chaperone
    14 of 14
    607783
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    boca - Art4
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - BI-1
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - Bap60
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - CCT3
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - CCT8
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - CG13630
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - CG17002
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - CG1889
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - CG3008
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - CG3045
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - CG34159
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - CG3570
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - CG9467
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - CSN4
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - Cdk8
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - Chc
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - Cnx99A
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - Cpr67B
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - Cpsf5
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - Cpsf6
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - Cyp9b2
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - Fim
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - Fmo2
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - Gk1
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - Glt
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - Gp210
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - Gtpbp2
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - HnRNP-K
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - Idh3a
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - Larp4B
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - LpR2
    anti tag coimmunoprecipitation, anti tag western blot
    (Culi et al., 2004)
    boca - MED10
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - MED11
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - MED14
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - MED15
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - MED16
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - MED17
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - MED18
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - MED20
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - MED23
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - MED27
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - MED30
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - MED4
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - MED6
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - MED7
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - MED8
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - Mpcp2
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - Nacα
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - Nup358
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - Pa1
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - Pi3K68D
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - Pih1D1
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - Psi
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - Ptip
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - Rdh1
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - RpLP0
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - RpS10b
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - RpS19a
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - ScsβG
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - Ser7
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - SerRS
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - TER94
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - UQCR-6.4
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - UQCR-C2
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - Usp10
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - bor
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - cPges
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - dsh
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - eIF3j
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - ebi
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - ix
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - mor
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - r
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - scf
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - vkg
    experimental knowledge based
    (Guruharsha et al., 2011)
    boca - α-Spec
    experimental knowledge based
    (Guruharsha et al., 2011)
    Summary of Genetic Interactions
    Interaction Browsers
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Subunit Structure (UniProtKB)
    Monomer (By similarity). Interacts with Arrow and Yolkless.
    (UniProt, Q8T9B6 )
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyBase
    External Links
    External Data
    Linkouts
    Class of Gene
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2R
    Recombination map
    2-56
    Cytogenetic map
    43D7-43D7
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    43D7-43D7
    Limits computationally determined from genome sequence between P{EP}CG1600EP398 and P{PZ}scra03427&P{EP}EP2179
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location

    2-56

    (FlyBase, 2016)

    2-56.7

    (Comeron et al., 2012)

    2-[57]

    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (8)
    Genomic Clones (9)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (6)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Cell Line Information
    Publicly Available Cell Lines
     
      Other Stable Cell Lines
       
        Other Comments

        boca is an essential component of the wg pathway but is more generally required for the activities of multiple LDL receptor family members.

        (Culi and Mann, 2003)

        boca is essential for proboscis development, and viability.

        (Culi and Mann, 2002)

        dsRNA causes embryos to develop into adults with reduced or absent proboscis but other fly body parts are apparently normal.

        (Culi and Mann, 2002)
        Relationship to Other Genes
        Source for database merge of

        Source for merge of: CG30498 l(2)43Ea

        (Culi, 2002.3.22)
        Additional comments

        Annotation CG1364 split into CG30499 and CG30498 (boca) in release 3 of the genome annotation.

        (FlyBase Genome Annotators, 2002-2003)
        Nomenclature History
        Source for database identify of
        Nomenclature comments
        Etymology

        'boca' means mouth in Catalan.

        (Culi and Mann, 2002)
        Synonyms and Secondary IDs (7)
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        Study result (0)
        Result
        Result Type
        Title
        External Crossreferences and Linkouts ( 31 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        Other crossreferences
        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
        FlyMine - An integrated database for Drosophila genomics
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL - MARRVEL (model organism gene)
        PDB - An information portal to biological macromolecular structures
        Linkouts
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        MIST (protein-protein) - An integrated Molecular Interaction Database
        References (72)