Smurnyy, Y., Toms, A.V., Hickson, G.R., Eck, M.J., Eggert, U.S. (2010). Binucleine 2, an isoform-specific inhibitor of Drosophila Aurora B kinase, provides insights into the mechanism of cytokinesis. ACS Chem. Biol. 5(11): 1015--1020.
FlyBase ID
FBrf0213546
Publication Type
Letter
Abstract
Aurora kinases are key regulators of cell division and important targets for cancer therapy. We report that Binucleine 2 is a highly isoform-specific inhibitor of Drosophila Aurora B kinase, and we identify a single residue within the kinase active site that confers specificity for Aurora B. Using Binucleine 2, we show that Aurora B kinase activity is not required during contractile ring ingression, providing insight into the mechanism of cytokinesis.
