FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
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Reference
Citation
Ge, D.T., Zamore, P.D. (2013). Small RNA-directed silencing: the fly finds its inner fission yeast?  Curr. Biol. 23(8): R318--R320.
FlyBase ID
FBrf0223577
Publication Type
Note
Abstract
Several recent studies demonstrate that piRNAs guide Piwi protein to repress transposon transcription in fly ovaries, much as fission yeast use siRNAs to silence repeat sequences. Still mysterious though is how Piwi targets euchromatic transposons for silencing, but not the specialized heterochromatic loci that produce piRNA precursors.
PubMed ID
23618667
PubMed Central ID
DOI
10.1016/j.cub.2013.03.033
Related Publication(s)
Research paper

Transcriptional silencing of transposons by piwi and maelstrom and its impact on chromatin state and gene expression.
Sienski et al., 2012, Cell 151(5): 964--980 [FBrf0220033]

Piwi induces piRNA-guided transcriptional silencing and establishment of a repressive chromatin state.
Le Thomas et al., 2013, Genes Dev. 27(4): 390--399 [FBrf0220858]

A Major Epigenetic Programming Mechanism Guided by piRNAs.
Huang et al., 2013, Dev. Cell 24(5): 502--516 [FBrf0221025]

Multiple roles for Piwi in silencing Drosophila transposons.
Rozhkov et al., 2013, Genes Dev. 27(4): 400--412 [FBrf0220849]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Curr. Biol.
    Title
    Current Biology
    Publication Year
    1991-
    ISBN/ISSN
    0960-9822
    Data From Reference
    Genes (1)