Maloney, K.N., Fujita, M., Eggert, U.S., Schroeder, F.C., Field, C.M., Mitchison, T.J., Clardy, J. (2008). Actin-aggregating cucurbitacins from Physocarpus capitatus. J. nat. Prod. 71(11): 1927--1929.
FlyBase ID
FBrf0231790
Publication Type
Research paper
Abstract
Bioassay-guided fractionation of Physocarpus capitatus yielded two new cucurbitacins (3 and 4) along with the known cucurbitacin F (1) and dihydrocucurbitacin F (2). Preliminary mechanism of action studies indicate that the cucurbitacins cause actin aggregates and inhibit cell division.
