Baker, N.E., Kale, A. (2016). Mutations in ribosomal proteins: Apoptosis, cell competition, and cancer.  Mol. Cell. Oncol. 3(1): e1029065.

FBrf0232635

Review

Mutations affecting multiple ribosomal proteins are implicated in cancer. Using genetic mosaics in the fruit fly Drosophila, we describe 3 apoptotic mechanisms that affect Rp/Rp homozygous mutant cells, Rp/+ heterozygous cells, or Rp/+ heterozygous cells in competition with nearby wild type cells, and discuss how apoptosis might be related to cancer predisposition.

PMC4845181 (PMC) (EuropePMC)