FB2026_03 , released September 17, 2026
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Citation
Manning, L.A., Peifer, M. (2019). Getting into shape: tissue tension drives oriented cell divisions during organogenesis.  EMBO J. 38(3): e101246.
FlyBase ID
FBrf0244369
Publication Type
Note
Abstract
The shapes and architecture of the organs in the animal body develop through complex coordination of cell shape change, cell migration, and cell proliferation. Finegan et al (2019) use the simple model of the Drosophila ovary and elongation of each egg chamber to explore this process. They find that a gradient of myosin‐driven tension exists along the axis of organ elongation and that this orients the division of the constituent cells. This and other recent work highlight how tissue‐level tension plays a key role in regulating tissue architecture.
PubMed ID
PubMed Central ID
PMC6356058 (PMC) (EuropePMC)
Related Publication(s)
Research paper

Tissue tension and not interphase cell shape determines cell division orientation in the Drosophila follicular epithelium.
Finegan et al., 2019, EMBO J. 38(3): e100072 [FBrf0241334]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    EMBO J.
    Title
    The EMBO Journal
    Publication Year
    1982-
    ISBN/ISSN
    0261-4189
    Data From Reference