The Gal4 line used was 4xHand-Gal4, constructed previously in the laboratory of Dr. Zhe Han. For RNAi lines (below), the number with v means it is from VDRC, the rest are from BDSC. Listed in each line below: the human gene name, the orthologous fly gene used, the RNAi lines used. UBB Ubi-p63E 33405, v102379 EIF4G3 eIF4G1 33049, v17002, 36879 METTL23 CG5013 v48108, v102140 SREBF1 SREBP 25975, 34073 CHD7 kismet 44542, 36597 PRKCB Pkc53E 34716, 55864 FRYL fry 60103, v103569 XPOT <up>no orthologous gene identified in Drosophila</up>