We tested 66258 (y1 w*; M{UAS-hPDE6B.HA}ZH-86Fb)
by crossing to 5535 (w*; P{w+m*=GAL4-ey.H}4-8/CyO) and saw flies with very strange eye phenotype. The flies had disrupted eye structure as well as three dimensional outgrowth structures that looked like non-pigmented tissue coming out of the eye.
Controls of 66258 insertion with CyO (no driver) were total normal.
We also tested the following two other human PDE stocks and did not see this phenotype.
78520 y1 w*; PBac{UAS-hPDE11A.B}VK00037
79166 y1 w*; PBac{UAS-hPDE4D.HA}VK00037
We can provide cell-phone taken images if anyone wants to see it.