Abstract
In this review we recall a number of important discoveries that took place in Drosophila during the seventies and eighties of the last century. The development of cell lineage methods and of powerful modifications of same, such as the Minute technique, led to the discovery of compartments and provided a clearer picture of the body organization: that came to be seen as a chain of metameric lineage units along the A/P body axis. Further, genetic screens allowed the identification of the genes involved in the establishment of the metameric scaffold - the segmentation genes- and also of Hox genes that are responsible for the specific development of individual body parts. As cloning methods became available, many of the most relevant of these developmental genes were cloned and a molecular analysis of development initiated. The discovery of the homeobox, a molecular mark of Hox and other relevant developmental genes, allowed the finding of Hox genes in animal species, like humans, in which they could not be identified by genetic methods. Analysis of the structure and function of Hox genes provided a general image of the genetic design of the metazoan body.
