Symbol
Dmel\P{neoFRT}18A
Species
D. melanogaster
Name
FlyBase ID
FBti0002070
Affected gene(s)
Viability / fertility
Associated allele(s)
Stock availability
Chromosomal Location
X
(
18A
)
Sequence Location
Member of Large Scale Dataset(s)
Cytological location (computed by FlyBase)
Cytological location (reported)
18A (in situ hybridization reported)
Insertion into Natural transposon
Comments concerning location
Insertion may affect gene
Variant Molecular Consequences
Associated Allele
Phenotypic Data
Reporter construct used in assay
Origin as a multiple insertion line
Progenitor(s) within the Genome
Related Aberration or Balancer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
In the presence of continuous Scer\FLP1, P{neoFRT}18A is >75% lethal and 100% of the escapers have severe eye and head defects. The lethality and developmental abnormalities are observed with both male and female flies carrying an P{neoFRT}18A chromosome, so the defects are not due to inter-chromosomal recombination. The P{neoFRT}18A chromosome may carry an aberration (perhaps another FRT site near the one at 18A) and that this has been transmitted to recombinant chromosomes carrying P{neoFRT}18A. I further suspect that recombination between the two FRT sites deletes essential genes, leading to cell lethality and head defects. Wing disc development is disrupted in flies carrying P{neoFRT}18A and Scer\GAL4ap-md544, a continuous source of Scer\FLP1 in the wing. Thus P{neoFRT}18A probably is cell lethal in the presence of continuous Scer\FLP1.
Used to generate mosaics mediated by FLP recombinase; P{neoFRT} insertion at proximal location in chromosome arm.