Pleckstrin homology domain of the Homo sapiens pleckstrin homology domain containing A3 (PLEKHA3) gene (HGNC:14338). This domain binds specifically to phosphatidylinositol-4-phosphate (PMID:11001876, PMID:15107860). This domain can thus be used to monitor the distribution of phosphatidylinositol-4-phosphate within a cell, if fused to an appropriate reporter protein, or to target a tagged protein to a particular subcellular localization via phosphatidylinositol-4-phosphate binding.