ChRWR is a light-gated cation channel that can be used as an optogenetic tool to activate neurons; it is sensitive to wavelengths 480-540nm, has a large effective conductance when expressed in HEK293 cells and its photocurrent desensitization is almost negligible. Its properties make it a good tool to stimulate neurons repetitively with low intensity flash light. ChRWR is an artificial channelrhodopsin that combines sequence from the ChR1 and ChR2 genes of Chlamydomonas reinhardtii; it consists of the extracellular N-terminus and transmembrane domains A-E of ChR1 and transmembrane domains F-G of ChR2 (PMID:19103605).