Scer\FRT-y+t7.7 cassette has been excised, juxtaposing Act5C promoter with mutated Mmus\Pkaca coding sequences (mC*).
The Scer\FRT cassette has been excised, juxtaposing the Act5C promoter with sequences encoding a constitutively active form of Mmus\Pkaca.
report comment: The mouse PKA allele carried in this construct is constitutively active (reduced binding to regulatory subunit). PKA coding sequence terminates with human growth hormone polyA signal.