FB2026_02 , released June 18, 2026
Recombinant Construct: P{PEPC-Psn.E280A}
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General Information
Symbol
P{PEPC-Psn.E280A}
FlyBase ID
FBtp0022071
Feature type
transgenic_transposable_element
Component Allele(s)
PsnE280A.PEPC.L
Size
Expression Data
Associated insertion(s)
1 available
Molecular map
Description and Uses
Construct components
Component allele PsnE280A.PEPC.L
Transgenic product class
missense_variant
(Seidner et al., 2006)
Component
Use(s)
Regulatory region(s)
Psn
Encoded product / tool
Psn
Description

A 1.5kb Psn promoter regulatory sequence (PEPC - Psn endogenous promoter cassette) drives expression of the longer isoform of Psn, mutated to carry an amino acid substitution that is equivalent to a E280A mutation in the orthologous human PSEN1 gene, a variant associated with familial Alzheimer disease.

(Seidner et al., 2006)
Sequence Data
Sequence (FB)
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA Sequence
Extent
Segments and Size
Total Size
Left end
Right end
 
Segments
Num
Orientation
Symbol
Reference
Phenotypic Data
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Progenitors and Descendants
progenitor(s)
descendant(s)
Comments
Stocks (0)
Stocks containing insertion(s) of this recombinant construct
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
E280A
(Seidner et al., 2006)
PEPC-psnE280A
(Seidner et al., 2006)
P{PEPC-Psn.E280A}
(FlyBase, 1992-)
Secondary FlyBase IDs
    References (3)