FB2026_02 , released June 18, 2026
Recombinant Construct: P{UAS-APP.770.K670N.M671L.E693G.VTR}
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General Information
Symbol
P{UAS-APP.770.K670N.M671L.E693G.VTR}
FlyBase ID
FBtp0064409
Feature type
transgenic_transposable_element
Component Allele(s)
Hsap\APP770.K670N.M671L.E693G.UAS.VTR
Size
Expression Data
Associated insertion(s)
2 available
Molecular map
Description and Uses
Construct components
Component allele Hsap\APP770.K670N.M671L.E693G.UAS.VTR
Transgenic product class
missense_variant
(Singh and Mahoney, 2011.2.17)
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\APP
Description

UAS drives expression of the 770 aa isoform of Hsap\APP carrying the familial Alzheimer's "Swedish" (K670N, M671L) and "Arctic" (E693G) mutations (amino acid numbering based on Hsap\APP sequence).

(Singh and Mahoney, 2011.2.17)
Sequence Data
Sequence (FB)
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA Sequence
Extent
Segments and Size
Total Size
Left end
Right end
 
Segments
Num
Orientation
Symbol
Reference
Phenotypic Data
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Progenitors and Descendants
progenitor(s)
descendant(s)
Comments
Stocks (1)
Stocks containing insertion(s) of this recombinant construct
Bloomington
33794
y1 w1118; P{UAS-APP.770.K670N.M671L.E693G.VTR}7
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
P{UAS-APP.770.K670N.M671L.E693G.VTR}
(Singh and Mahoney, 2011.2.17, FlyBase, 1992-)
UAS-AppNLG
(Yadav et al., 2026)
Secondary FlyBase IDs
    References (5)