GMR regulatory sequences drive expression of an oligonucleotide encoding wild type Hsap\MAPT with mutations at 11 of 14 major serine/threonine sgg phosphorylation sites: S46A, T50A, S199A, T202A, T205A, T212A, S214A, T231A, S235A, S396A and S404A. The two amino terminal inserts generated by alternative splicing of Hsap\MAPT exons 2 and 3 are included.