FB2026_03 , released September 17, 2026
Recombinant Construct: P{UAS-Torsin.ΔE}
Open Close
General Information
Symbol
P{UAS-Torsin.ΔE}
FlyBase ID
FBtp0092286
Feature type
transgenic_transposable_element
Component Allele(s)
TorsinΔE.UAS
Size
Expression Data
Associated insertion(s)
1 available
Molecular map
Description and Uses
Construct components
Component allele TorsinΔE.UAS
Transgenic product class
dominant_negative_variant
(Wakabayashi-Ito et al., 2015)
inframe_deletion
(Wakabayashi-Ito et al., 2015, Jokhi et al., 2013)
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Torsin
Description

UAS regulatory sequences drive expression of Torsin in which the amino acid residue E306 has been deleted. This results in a dominant-negative protein.

(Wakabayashi-Ito et al., 2015)

UAS regulatory sequences drive expression of Torsin containing a deletion of amino acid residue E306. (FlyBase curator comment: FBrf0223228 states that this change is equivalent to a pathogenic mutation (deletion of E303) in the orthologous human TOR1A gene, a change that is dominantly linked to dystonia. However, comparative alignment of the two genes suggests that E303 in the human gene falls in a region that does not appear to be conserved between the two species, and that E306 in the D. melanogaster Torsin gene is analogous to E294 in the human TOR1A gene).

(Jokhi et al., 2013)
Sequence Data
Sequence (FB)
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA Sequence
Extent
Segments and Size
Total Size
Left end
Right end
 
Segments
Num
Orientation
Symbol
Reference
Phenotypic Data
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Progenitors and Descendants
progenitor(s)
descendant(s)
Comments
Stocks (0)
Stocks containing insertion(s) of this recombinant construct
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
P{UAS-Torsin.ΔE}
(FlyBase, 1992-)
pUAST-dtorsinΔE
(Wakabayashi-Ito et al., 2015)
Secondary FlyBase IDs
    References (4)