FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Recombinant Construct: M{UAS-MmusPrnp.3F4.FFI}
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General Information
Symbol
M{UAS-Mmus\Prnp.3F4.FFI}
FlyBase ID
FBtp0130789
Feature type
transgenic_transposable_element
Component Allele(s)
Mmus\PrnpFFI.3F4.UAS
Size
Expression Data
Associated insertion(s)
2 available
Molecular map
Description and Uses
Construct components
Component allele Mmus\PrnpFFI.3F4.UAS
Transgenic product class
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Mmus\Prnp
Description

UASt drives expression of the mature Mmus\Prnp 3F4 protein (the 3F4 epitope is created via two amino acid substitutions, L108M and V111M, and is already present in wild-type human and hamster PrP) carrying a single-codon mutation (D177N) associated with fatal familial insomnia (FFI) prion disease in humans, flanked by the coding sequence of its autologous leader peptide and GPI signal sequence.

(Thackray et al., 2017)
Sequence Data
Sequence (FB)
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA Sequence
Extent
Segments and Size
Total Size
Left end
Right end
 
Segments
Num
Orientation
Symbol
Reference
Phenotypic Data
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Progenitors and Descendants
progenitor(s)
descendant(s)
Comments
Stocks (0)
Stocks containing insertion(s) of this recombinant construct
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
3F4 D177N
(Thackray et al., 2017)
M{UAS-Mmus\Prnp.3F4.FFI}
(FlyBase, 1992-)
mo3F4FFI
(Thackray et al., 2017)
Secondary FlyBase IDs
    References (3)