FB2026_02 , released June 18, 2026
Recombinant Construct: P{UAS-hMAPT.E14D421A}
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General Information
Symbol
P{UAS-hMAPT.E14D421A}
FlyBase ID
FBtp0144086
Feature type
transgenic_transposable_element
Component Allele(s)
Hsap\MAPTE14D421A.UAS
Size
Expression Data
Associated insertion(s)
1 available
Molecular map
Description and Uses
Construct components
Component allele Hsap\MAPTE14D421A.UAS
Transgenic product class
missense_variant
(Chi et al., 2020)
polypeptide_post_translational_processing_variant
(Chi et al., 2020)
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\MAPT
Description

UASt regulates expression of the full-length 2N4R form of Hsap\MAPT in which 14 Ser/Thr sites (Thr111, Thr153, Ser175, Thr181, Ser199, Ser202, Thr205, Thr212, Thr217, Thr231, Ser235, Ser396, Ser404 and Ser422) are changed to glutamic acids, mimicking pseudo-phosphorylation, and Asp421 is changed to alanine mimicking non-cleavage at Asp421. Phosphorylation status affects pathogenicity in human patients and the truncated form is associated with Alzheimer's Disease.

(Chi et al., 2020)
Sequence Data
Sequence (FB)
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA Sequence
Extent
Segments and Size
Total Size
Left end
Right end
 
Segments
Num
Orientation
Symbol
Reference
Phenotypic Data
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Progenitors and Descendants
progenitor(s)
descendant(s)
Comments
Stocks (0)
Stocks containing insertion(s) of this recombinant construct
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
E14D421A
(Chi et al., 2020)
P{UAS-hMAPT.E14D421A}
(FlyBase, 1992-)
Secondary FlyBase IDs
    References (3)