FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Recombinant Construct: P{UAS-hMAPT.E14421}
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General Information
Symbol
P{UAS-hMAPT.E14421}
FlyBase ID
FBtp0144087
Feature type
transgenic_transposable_element
Component Allele(s)
Hsap\MAPTE14421.UAS
Size
Expression Data
Associated insertion(s)
1 available
Molecular map
Description and Uses
Construct components
Component allele Hsap\MAPTE14421.UAS
Transgenic product class
inframe_deletion
(Chi et al., 2020)
missense_variant
(Chi et al., 2020)
polypeptide_post_translational_processing_variant
(Chi et al., 2020)
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\MAPT
Description

UASt regulates expression of residues 1-421 of the 2N4R form of Hsap\MAPT, mimicking the full-length form truncated at the Asp421 site, and in which 14 Ser/Thr sites (Thr111, Thr153, Ser175, Thr181, Ser199, Ser202, Thr205, Thr212, Thr217, Thr231, Ser235, Ser396, Ser404 and Ser422) are changed to glutamic acids, mimicking pseudo-phosphorylation. Phosphorylation status affects pathogenicity in human patients and the truncated form is associated with Alzheimer's Disease.

(Chi et al., 2020)
Sequence Data
Sequence (FB)
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA Sequence
Extent
Segments and Size
Total Size
Left end
Right end
 
Segments
Num
Orientation
Symbol
Reference
Phenotypic Data
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Progenitors and Descendants
progenitor(s)
descendant(s)
Comments
Stocks (0)
Stocks containing insertion(s) of this recombinant construct
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
E14421
(Chi et al., 2020)
P{UAS-hMAPT.E14421}
(FlyBase, 1992-)
Secondary FlyBase IDs
    References (3)