FB2026_03 , released September 17, 2026
CV Term Report
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Term RNA polymerase I general transcription initiation factor activity ID (Ontology) GO:0001181 (Gene Ontology)
Definition A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase I. Factors required for RNA polymerase I transcription initiation include upstream activation factor (UAF), core factor (CF), TATA binding protein (TBP) and RRN3. In all species characterized, RNA polymerase I transcribes a large polycistronic transcript that is processed into several mature rRNAs (3 or 4 depending on the species), including the large subunit rRNA (28S in humans), the small subunit rRNA (18S in humans), as well as one or two additional smaller rRNAs (the 5.8S rRNA in humans). In most species, this large rRNA transcript is the sole product of RNA polymerase I. However there are rare exceptions, such as Trypanosoma brucei, where RNA polymerase I also transcribes certain mRNAs.[ PubMed:11500378 PubMed:17972917 PubMed:25346433 PubMed:28340337 PubMed:28842442 PubMed:31358304 ]
Also Known As"general RNA polymerase I transcription factor activity" ; "RNA polymerase I transcription general initiation factor activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 RNA polymerase I general transcription initiation factor activity (all annotations which use CV term, excluding "NOT" statements)
     contributes_to | RNA polymerase I general transcription initiation factor activity
     enables | RNA polymerase I general transcription initiation factor activity
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   |__general transcription initiation factor activity
       |__RNA polymerase I general transcription initiation factor activity  1 rec.
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Synonyms
  • "core RNA polymerase I binding transcription factor activity" BROAD
    "general RNA polymerase I transcription factor activity" EXACT
    "RNA polymerase I transcription general initiation factor activity" EXACT
    "transcription factor activity, core RNA polymerase I binding" BROAD
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