FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term cytochrome-c oxidase activity ID (Ontology) GO:0004129 (Gene Ontology)
Definition Catalysis of the reaction: 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out).
Also Known As"cytochrome c oxidase activity"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_CELLULAR_COMPONENT
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 Gene Groups Genes
 cytochrome-c oxidase activity (all annotations which use CV term, excluding "NOT" statements)
     contributes_to | cytochrome-c oxidase activity       --
     enables | cytochrome-c oxidase activity       --
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molecular_function
 |__electron transfer activity_______________________________________
monoatomic cation transmembrane transporter activity                 |
 |__proton transmembrane transporter activity________________________|
monoatomic ion transmembrane transporter activity                    |
 |__active monoatomic ion transmembrane transporter activity_________|
primary active transmembrane transporter activity                    |
 |__oxidoreduction-driven active transmembrane transporter activity__|
 |__active monoatomic ion transmembrane transporter activity_________|
oxidoreductase activity                                              |
 |__oxidoreductase activity, acting on a heme group of donors________|
                                                                     cytochrome-c oxidase activity  7 rec.
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Is a electron transfer activity
proton transmembrane transporter activity
oxidoreduction-driven active transmembrane transporter activity
oxidoreductase activity, acting on a heme group of donors
active monoatomic ion transmembrane transporter activity
Part of
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Synonyms
  • "aa3-type cytochrome c oxidase" NARROW[ EC:7 ]
    "ba3-type cytochrome c oxidase" NARROW[ EC:7 ]
    "caa3-type cytochrome c oxidase" NARROW[ EC:7 ]
    "cbb3-type cytochrome c oxidase" NARROW[ EC:7 ]
    "complex IV (mitochondrial electron transport) activity" RELATED[ EC:7 ]
    "cytochrome a3 activity" NARROW[ EC:7 ]
    "cytochrome aa3 activity" NARROW[ EC:7 ]
    "cytochrome c oxidase activity" EXACT
    "cytochrome oxidase activity" RELATED[ EC:7 ]
    "indophenol oxidase" NARROW
    "indophenolase" NARROW
    "Warburg's respiratory enzyme activity" RELATED[ EC:7 ]
Secondary IDs
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EC:7.1.1.9
MetaCyc:CYTOCHROME-C-OXIDASE-RXN
Reactome:R-HSA-163214 "Electron transfer from reduced cytochrome c to molecular oxygen"
RHEA:11436