FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term thioredoxin-disulfide reductase (NADPH) activity ID (Ontology) GO:0004791 (Gene Ontology)
Definition Catalysis of the reaction: thioredoxin-dithiol + NADP+ = thioredoxin-disulfide + H+ + NADPH.
Also Known As "NADPH:oxidized thioredoxin oxidoreductase activity" ; "thioredoxin reductase (NADPH) activity" ; "thioredoxin-disulfide reductase (NADP) activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 thioredoxin-disulfide reductase (NADPH) activity (all annotations which use CV term, excluding "NOT" statements)
     enables | thioredoxin-disulfide reductase (NADPH) activity       --
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molecular_function
 |__antioxidant activity_________________________________________________________
protein-disulfide reductase activity                                             |
 |__protein-disulfide reductase [NAD(P)H] activity_______________________________|
oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor  |
 |__protein-disulfide reductase [NAD(P)H] activity_______________________________|
                                                                                 thioredoxin-disulfide reductase (NADPH) activity  4 rec.
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Is a antioxidant activity
protein-disulfide reductase [NAD(P)H] activity
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Synonyms
  • "NADPH:oxidized thioredoxin oxidoreductase activity" EXACT[ EC:1 ]
    "thioredoxin disulfide reductase activity" BROAD
    "thioredoxin reductase (NADPH) activity" EXACT
    "thioredoxin-disulfide reductase (NADP) activity" EXACT
    "thioredoxin-disulfide reductase activity" BROAD
    "thioredoxin-disulphide reductase activity" BROAD
Secondary IDs
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EC:1.8.1.9
KEGG_REACTION:R02016
MetaCyc:THIOREDOXIN-REDUCT-NADPH-RXN
Reactome:R-HSA-1222485 "TrxB reactivates TrxA"
Reactome:R-HSA-3323050 "TXNRD2 catalyzes the reduction of TXN2 by NADPH"
Reactome:R-HSA-73646 "Regeneration of active (reduced) Thioredoxin"
Reactome:R-HSA-9617735 "TXN disrupts FOXO4 complex with EP300"
RHEA:20345