FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term microtubule severing ATPase activity ID (Ontology) GO:0008568 (Gene Ontology)
Definition Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP.[ PubMed:10910766 ]
Also Known As"ATP phosphohydrolase (tubulin-dimerizing)" ; "microtubule-severing ATPase activity"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 microtubule severing ATPase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | microtubule severing ATPase activity       --
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molecular_function
 |__ATP-dependent activity___________________________________
catalytic activity                                           |
 |__catalytic activity, acting on a protein__________________|
macromolecular conformation isomerase activity               |
 |__polypeptide conformation or assembly isomerase activity__|
protein-containing complex destabilizing activity            |
 |__microtubule destabilizing activity_______________________|
                                                             microtubule severing ATPase activity  6 rec.
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Is a polypeptide conformation or assembly isomerase activity
catalytic activity, acting on a protein
ATP-dependent activity
microtubule destabilizing activity
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Synonyms
  • "ATP phosphohydrolase (tubulin-dimerizing)" EXACT
    "katanin activity" NARROW[ EC:5 ]
    "microtubule-severing ATPase activity" EXACT
Secondary IDs
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EC:5.6.1.1
MetaCyc:3.6.4.3-RXN
Reactome:R-HSA-9668419 "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites"