FB2026_03 , released September 17, 2026
CV Term Report
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Term RNA polymerase II general transcription initiation factor activity ID (Ontology) GO:0016251 (Gene Ontology)
Definition A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP). In most species, RNA polymerase II transcribes all messenger RNAs (mRNAs), most untranslated regulatory RNAs, the majority of the snoRNAs, four of the five snRNAs (U1, U2, U4, and U5), and other small noncoding RNAs. For some small RNAs there is variability between species as to whether it is transcribed by RNA polymerase II or RNA polymerase III. However there are also rare exceptions, such as Trypanosoma brucei, where RNA polymerase I transcribes certain mRNAs in addition to its normal role in rRNA transcription.[ PubMed:10384286 PubMed:10747032 PubMed:23442138 PubMed:25693126 ]
Also Known As"basal RNA polymerase II transcription factor activity" ; "general RNA polymerase II transcription factor activity" ; "GTF2 activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 RNA polymerase II general transcription initiation factor activity (all annotations which use CV term, excluding "NOT" statements)
     contributes_to | RNA polymerase II general transcription initiation factor activity       --
     enables | RNA polymerase II general transcription initiation factor activity       --
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   |__general transcription initiation factor activity
       |__RNA polymerase II general transcription initiation factor activity  37 rec.
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Synonyms
  • "basal RNA polymerase II transcription factor activity" EXACT
    "general RNA polymerase II transcription factor activity" EXACT
    "GTF2 activity" EXACT
    "RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity" RELATED
    "RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly" RELATED
    "sequence-specific core promoter binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly" RELATED
    "transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly" RELATED
    "transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding" RELATED
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