FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term ligase activity ID (Ontology) GO:0016874 (Gene Ontology)
Definition Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient.[ EC:6 ]
Also Known As"synthetase activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 ligase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | ligase activity       --
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  molecular_function
   |__catalytic activity
       |__ligase activity  190 rec.
           |__ligase activity, forming carbon-carbon bonds 8 rec.
           |   |__2-oxoglutarate carboxylase activity
           |   |__acetone carboxylase activity
           |   |__CoA carboxylase activity(+) 5 rec.
           |   |__pyruvate carboxylase activity 2 rec.
           |__ligase activity, forming carbon-nitrogen bonds 45 rec.
           |   |__5-(carboxyamino)imidazole ribonucleotide synthase activity
           |   |__acid-amino acid ligase activity(+) 20 rec.
           |   |__acid-ammonia (or amide) ligase activity(+) 4 rec.
           |   |__adenylosuccinate synthase activity 1 rec.
           |   |__argininosuccinate synthase activity 1 rec.
           |   |__beta-alanyl amine synthase activity 1 rec.
           |   |__biotin carboxylase activity
           |   |__biotin--[biotin carboxyl-carrier protein] ligase activity 1 rec.
           |   |__carbamoyl-phosphate synthase (ammonia) activity
           |   |__carbon-nitrogen ligase activity, with glutamine as amido-N-donor(+) 9 rec.
           |   |__citrate-L-glutamate ligase activity
           |   |__CTP synthase activity 1 rec.
           |   |__cyclo-ligase activity(+) 3 rec.
           |   |__formate-dihydrofolate ligase activity
           |   |__formate-tetrahydrofolate ligase activity 1 rec.
           |   |__glutamate-methylamine ligase activity
           |   |__GMP synthase activity 1 rec.
           |   |__imidazoleacetate-phosphoribosyldiphosphate ligase activity
           |   |__indole-3-acetyl-glycine synthetase activity
           |   |__indole-3-acetyl-isoleucine synthetase activity
           |   |__indole-3-acetyl-methionine synthetase activity
           |   |__N-acetyl-L-aspartate-L-glutamate ligase activity
           |   |__nicotinate phosphoribosyltransferase activity 1 rec.
           |   |__phosphoribosylamine-glycine ligase activity 1 rec.
           |   |__ribose-5-phosphate-ammonia ligase activity
           |   |__tRNA(Ile)-lysidine synthase activity
           |   |__urea carboxylase activity
           |__ligase activity, forming carbon-oxygen bonds 44 rec.
           |   |__aminoacyl-tRNA ligase activity(+) 43 rec.
           |   |__D-alanine-(R)-lactate ligase activity
           |__ligase activity, forming carbon-sulfur bonds 54 rec.
           |   |__acid-thiol ligase activity(+) 36 rec.
           |   |__ubiquitin-like modifier activating enzyme activity(+) 16 rec.
           |__ligase activity, forming nitrogen-metal bonds
           |   |__ligase activity, forming nitrogen-metal bonds, forming coordination complexes(+)
           |__ligase activity, forming phosphoric ester bonds 9 rec.
           |   |__DNA ligase activity(+) 4 rec.
           |   |__peptide lactyltransferase (ATP-dependent) activity
           |   |__RNA ligase activity(+) 2 rec.
           |   |__RNA-3'-phosphate cyclase activity 2 rec.
           |__proton-transporting ATP synthase activity, rotational mechanism 29 rec.
           |__sodium-transporting ATP synthase activity, rotational mechanism
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Synonyms
  • "synthetase activity" EXACT
Secondary IDs
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EC:6.-.-.-