FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term ligase activity ID (Ontology) GO:0016874 (Gene Ontology)
Definition Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient.[ EC:6 ]
Also Known As "synthetase activity"
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Annotations
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       5
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 ligase activity (all annotations which use CV term, excluding "NOT" statements)       1      5
     enables | ligase activity       --       5
Spanning Tree (Parents/Children)
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  molecular_function
   |__catalytic activity
       |__ligase activity  191 rec.
           |__ligase activity, forming carbon-carbon bonds 8 rec.
           |   |__2-oxoglutarate carboxylase activity
           |   |__acetone carboxylase activity
           |   |__CoA carboxylase activity(+) 5 rec.
           |   |__pyruvate carboxylase activity 2 rec.
           |__ligase activity, forming carbon-nitrogen bonds 47 rec.
           |   |__5-(carboxyamino)imidazole ribonucleotide synthase activity
           |   |__acid-amino acid ligase activity(+) 20 rec.
           |   |__acid-ammonia (or amide) ligase activity(+) 4 rec.
           |   |__adenylosuccinate synthase activity 1 rec.
           |   |__argininosuccinate synthase activity 1 rec.
           |   |__beta-alanyl amine synthase activity 1 rec.
           |   |__biotin carboxylase activity 1 rec.
           |   |__biotin--[biotin carboxyl-carrier protein] ligase activity 1 rec.
           |   |__carbamoyl-phosphate synthase (ammonia) activity
           |   |__carbon-nitrogen ligase activity, with glutamine as amido-N-donor(+) 10 rec.
           |   |__citrate-L-glutamate ligase activity
           |   |__CTP synthase activity 1 rec.
           |   |__cyclo-ligase activity(+) 3 rec.
           |   |__formate-dihydrofolate ligase activity
           |   |__formate-tetrahydrofolate ligase activity 1 rec.
           |   |__glutamate-methylamine ligase activity
           |   |__GMP synthase activity 1 rec.
           |   |__imidazoleacetate-phosphoribosyldiphosphate ligase activity
           |   |__indole-3-acetyl-glycine synthetase activity
           |   |__indole-3-acetyl-isoleucine synthetase activity
           |   |__indole-3-acetyl-methionine synthetase activity
           |   |__lipoate-protein ligase activity
           |   |__N-acetyl-L-aspartate-L-glutamate ligase activity
           |   |__nicotinate phosphoribosyltransferase activity 1 rec.
           |   |__phosphoribosylamine-glycine ligase activity 1 rec.
           |   |__ribose-5-phosphate-ammonia ligase activity
           |   |__tRNA(Ile)-lysidine synthase activity
           |   |__urea carboxylase activity
           |__ligase activity, forming carbon-oxygen bonds 44 rec.
           |   |__aminoacyl-tRNA ligase activity(+) 43 rec.
           |   |__D-alanine-(R)-lactate ligase activity
           |__ligase activity, forming carbon-sulfur bonds 54 rec.
           |   |__acid-thiol ligase activity(+) 36 rec.
           |   |__CoA-ligase activity(+) 28 rec.
           |   |__ubiquitin-like modifier activating enzyme activity(+) 16 rec.
           |__ligase activity, forming nitrogen-metal bonds
           |   |__ligase activity, forming nitrogen-metal bonds, forming coordination complexes(+)
           |__ligase activity, forming phosphoric ester bonds 9 rec.
           |   |__DNA ligase activity(+) 4 rec.
           |   |__peptide lactyltransferase (ATP-dependent) activity
           |   |__RNA ligase activity(+) 2 rec.
           |   |__RNA-3'-phosphate cyclase activity 2 rec.
           |__proton-transporting ATP synthase activity, rotational mechanism 29 rec.
           |__sodium-transporting ATP synthase activity, rotational mechanism
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Is a catalytic activity
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Synonyms
  • "synthetase activity" EXACT
Secondary IDs
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EC:6.-.-.-