FB2026_03 , released September 17, 2026
CV Term Report
Help Close All Open All
General Information
Term receptor internalization ID (Ontology) GO:0031623 (Gene Ontology)
Definition A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.[ PubMed:15006537 PubMed:19643732 ]
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS

Choose a record type to view annotations for this term and its child terms. Direct annotations and full annotation statements below also provide HitList buttons.

    • Results list data from multiple species. Choose a record type above to open its HitList.
Direct annotations: records annotated with this exact term (child terms are NOT included)
Data ClassFieldDirect annotations
Genes (FBgn)GO_BIOLOGICAL_PROCESS
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 receptor internalization (all annotations which use CV term, excluding "NOT" statements)
     involved_in | receptor internalization
Spanning Tree (Parents/Children)
Only view relationship:
Vocabulary search 
endocytosis_________________
vesicle-mediated transport__|
                            receptor-mediated endocytosis
                             |__receptor internalization  17 rec.
                                 |__B cell receptor internalization
                                 |   |__positive regulation of toll-like receptor 9 signaling pathway by B cell receptor internalization
                                 |__G protein-coupled receptor internalization 4 rec.
                                 |   |__prostaglandin receptor internalization
                                 |   |__regulation of G protein-coupled receptor internalization(+)
                                 |__insulin receptor internalization
                                 |   |__negative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                 |   |__positive regulation of insulin receptor signaling pathway by insulin receptor internalization
                                 |__neurotransmitter receptor internalization 1 rec.
                                 |   |__postsynaptic neurotransmitter receptor internalization(+) 1 rec.
                                 |__regulation of receptor internalization 8 rec.
                                 |   |__negative regulation of receptor internalization(+) 1 rec.
                                 |   |__positive regulation of receptor internalization(+) 5 rec.
                                 |   |__regulation of G protein-coupled receptor internalization(+)
                                 |   |__regulation of postsynaptic neurotransmitter receptor internalization 1 rec.
                                 |__regulation of signal transduction by receptor internalization 1 rec.
                                 |   |__negative regulation of signal transduction by receptor internalization(+)
                                 |   |__positive regulation of signal transduction by receptor internalization(+) 1 rec.
                                 |__Wnt receptor internalization
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a receptor-mediated endocytosis
Part of
hide Synonyms & Secondary IDs
Synonyms
Secondary IDs
hide External Crossreferences & Linkouts