FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

positive regulation of signal transduction by receptor internalization

ID (Ontology)

GO:0038010 (Gene Ontology)

Definition

Any process in which the internalization of a signaling receptor activates or increases the frequency, rate or extent of signal transduction. Receptor internalization can enhance signaling by concentrating signaling molecules in one location, or by moving a ligand-activated receptor to the location of downstream signaling proteins. Endosomes for example can serve as important intracellular signaling platforms.[ PubMed:17908284 PubMed:19696798 ]

Also Known As

"positive regulation of signaling pathway by receptor endocytosis"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_BIOLOGICAL_PROCESS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
positive regulation of signal transduction by receptor internalization (all annotations which use CV term, excluding "NOT" statements)
involved_in \| positive regulation of signal transduction by receptor internalization

Spanning Tree (Parents/Children)

regulation of signal transduction
 |__positive regulation of signal transduction_____________________
 |__regulation of signal transduction by receptor internalization__|
positive regulation of cell communication                          |
 |__positive regulation of signal transduction_____________________|
positive regulation of signaling                                   |
 |__positive regulation of signal transduction_____________________|
receptor internalization                                           |
 |__regulation of signal transduction by receptor internalization__|
positive regulation of response to stimulus                        |
 |__positive regulation of signal transduction_____________________|
                                                                   positive regulation of signal transduction by receptor internalization  1 rec.
                                                                    |__positive regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                                    |__positive regulation of toll-like receptor 9 signaling pathway by B cell receptor internalization

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Relationships
Is a	positive regulation of signal transduction regulation of signal transduction by receptor internalization
Part of
Synonyms & Secondary IDs
Synonyms
	"positive regulation of signaling pathway by receptor endocytosis" EXACT
Secondary IDs

External Crossreferences & Linkouts