FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term cargo receptor activity ID (Ontology) GO:0038024 (Gene Ontology)
Definition Binding specifically to a substance (cargo) to deliver it to a transport vesicle. Cargo receptors span membranes (for instance the plasma membrane or the endoplasmic reticulum membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit the cargo molecules to nascent vesicles.[ PubMed:15239958 PubMed:27903609 ]
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 cargo receptor activity (all annotations which use CV term, excluding "NOT" statements)
     enables | cargo receptor activity
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  molecular_function
   |__cargo receptor activity  44 rec.
       |__alpha-2 macroglobulin receptor activity
       |__apolipoprotein receptor activity
       |   |__apolipoprotein A-I receptor activity
       |__asialoglycoprotein receptor activity
       |__COPII receptor activity 1 rec.
       |__ER lumen protein retrieval receptor activity 1 rec.
       |__ER membrane protein retrieval receptor activity
       |__ferritin receptor activity
       |__folic acid receptor activity
       |__heme receptor activity
       |__lactoferrin receptor activity
       |__lipoprotein particle receptor activity 3 rec.
       |   |__high-density lipoprotein particle receptor activity
       |   |__low-density lipoprotein particle receptor activity 1 rec.
       |   |__oxidised low-density lipoprotein particle receptor activity
       |   |__very-low-density lipoprotein particle receptor activity
       |__scavenger receptor activity 20 rec.
       |__transferrin receptor activity
       |__vacuolar sorting signal receptor activity
       |__vitellogenin receptor activity 1 rec.
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Synonyms
  • "endocytic receptor activity" NARROW[ ISBN:0123645387 PubMed:12671190 ]
    "receptor activity" BROAD
    "receptor activity involved in receptor-mediated endocytosis" NARROW
    "transport receptor activity" BROAD
Secondary IDs
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Reactome:R-HSA-203716 "eNOS:Caveolin-1 complex binds to Nostrin"
Reactome:R-HSA-2160915 "Receptor-mediated uptake of HA"
Reactome:R-HSA-3000103 "CUBN:AMN binds CBLIF:RCbl"
Reactome:R-HSA-3000112 "CD320-mediated TCN2:RCbl uptake and delivery to lysosome"
Reactome:R-HSA-3000122 "CD320 binds extracellular TCN2:RCbl"
Reactome:R-HSA-3000137 "CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome"
Reactome:R-HSA-350168 "LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D"
Reactome:R-HSA-350186 "CUBN binds GC:25(OH)D"
Reactome:R-HSA-9759202 "LRP2-mediated TCN2:RCbl uptake and delivery to lysosome"
Reactome:R-HSA-9759209 "LRP2 binds extracellular TCN2:RCbl"