FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term ERBB signaling pathway ID (Ontology) GO:0038127 (Gene Ontology)
Definition The series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptor tyrosine kinases on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.[ PubMed:16460914 ]
Also Known As "EGF receptor family signaling pathway" ; "ErbB signaling" ; "ERBB signalling pathway"
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       1
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 Genes
 ERBB signaling pathway (all annotations which use CV term, excluding "NOT" statements)       1
     involved_in | ERBB signaling pathway       1
Spanning Tree (Parents/Children)
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  enzyme-linked receptor protein signaling pathway
   |__cell surface receptor protein tyrosine kinase signaling pathway
       |__ERBB signaling pathway  85 rec.
           |__epidermal growth factor receptor signaling pathway 85 rec.
           |   |__ERBB2-EGFR signaling pathway
           |   |__ERBB4-EGFR signaling pathway
           |   |__regulation of epidermal growth factor receptor signaling pathway(+) 60 rec.
           |__ERBB2 signaling pathway
           |   |__ERBB2-EGFR signaling pathway
           |   |__ERBB2-ERBB3 signaling pathway
           |   |__ERBB2-ERBB4 signaling pathway
           |__ERBB3 signaling pathway
           |   |__ERBB2-ERBB3 signaling pathway
           |   |__ERBB3-ERBB4 signaling pathway
           |   |__regulation of ERBB3 signaling pathway(+)
           |__ERBB4 signaling pathway
           |   |__ERBB2-ERBB4 signaling pathway
           |   |__ERBB3-ERBB4 signaling pathway
           |   |__ERBB4-EGFR signaling pathway
           |   |__ERBB4-ERBB4 signaling pathway
           |__regulation of ERBB signaling pathway 60 rec.
               |__negative regulation of ERBB signaling pathway(+) 40 rec.
               |__positive regulation of ERBB signaling pathway(+) 19 rec.
               |__regulation of epidermal growth factor receptor signaling pathway(+) 60 rec.
               |__regulation of ERBB3 signaling pathway(+)
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Is a cell surface receptor protein tyrosine kinase signaling pathway
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