FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term neurotrophin TRK receptor signaling pathway ID (Ontology) GO:0048011 (Gene Ontology)
Definition The series of molecular signals initiated by neurotrophin binding to its receptor on the surface of a target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.[ PubMed:12065629 ]
Also Known As"tropomyosin-receptor-kinase signaling"
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Genes (FBgn)GO_BIOLOGICAL_PROCESS
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 neurotrophin TRK receptor signaling pathway (all annotations which use CV term, excluding "NOT" statements)
     involved_in | neurotrophin TRK receptor signaling pathway
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cell surface receptor signaling pathway
 |__neurotrophin signaling pathway___________________________________
enzyme-linked receptor protein signaling pathway                     |
 |__cell surface receptor protein tyrosine kinase signaling pathway__|
cellular response to growth factor stimulus                          |
 |__neurotrophin signaling pathway___________________________________|
                                                                     neurotrophin TRK receptor signaling pathway  1 rec.
                                                                      |__regulation of neurotrophin TRK receptor signaling pathway
                                                                          |__negative regulation of neurotrophin TRK receptor signaling pathway
                                                                          |__positive regulation of neurotrophin TRK receptor signaling pathway
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Is a cell surface receptor protein tyrosine kinase signaling pathway
neurotrophin signaling pathway
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Synonyms
  • "TrkA signaling pathway" NARROW
    "TrkB signaling pathway" NARROW
    "TrkC signaling pathway" NARROW
    "tropomyosin-receptor-kinase signaling" EXACT
Secondary IDs
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Reactome:R-HSA-166520 "Signaling by NTRKs"
Reactome:R-HSA-167021 "PLC-gamma1 signalling"
Reactome:R-HSA-187042 "TRKA activation by NGF"
Reactome:R-HSA-193704 "p75 NTR receptor-mediated signalling"