FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term mRNA destabilization ID (Ontology) GO:0061157 (Gene Ontology)
Definition Any process that decreases the stability of an mRNA molecule, making it more vulnerable to degradative processes. Messenger RNA is the intermediate molecule between DNA and protein. It includes UTR and coding sequences. It does not contain introns.
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Data ClassFieldDirect annotations
Genes (FBgn)GO_BIOLOGICAL_PROCESS
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 mRNA destabilization (all annotations which use CV term, excluding "NOT" statements)
     involved_in | mRNA destabilization
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positive regulation of catabolic process
 |__RNA destabilization____________________________________
 |__positive regulation of mRNA catabolic process__________|
regulation of gene expression                              |
 |__negative regulation of gene expression_________________|
negative regulation of macromolecule biosynthetic process  |
 |__negative regulation of gene expression_________________|
regulation of RNA stability                                |
 |__regulation of mRNA stability___________________________|
 |__RNA destabilization____________________________________|
positive regulation of RNA metabolic process               |
 |__RNA destabilization____________________________________|
regulation of mRNA catabolic process                       |
 |__regulation of mRNA stability___________________________|
 |__positive regulation of mRNA catabolic process__________|
positive regulation of mRNA metabolic process              |
 |__positive regulation of mRNA catabolic process__________|
                                                           mRNA destabilization  74 rec.
                                                            |__3'-UTR-mediated mRNA destabilization 5 rec.
                                                            |__miRNA-mediated gene silencing by mRNA destabilization 24 rec.
                                                            |__nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 32 rec.
                                                            |   |__deadenylation-dependent decapping of nuclear-transcribed mRNA(+) 8 rec.
                                                            |   |__nuclear-transcribed mRNA poly(A) tail shortening(+) 23 rec.
                                                            |   |__regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(+) 2 rec.
                                                            |__piRNA-mediated gene silencing by mRNA destabilization 12 rec.
                                                            |   |__transposable element silencing by piRNA-mediated mRNA destabilization 8 rec.
                                                            |__polyadenylation-dependent mRNA catabolic process
                                                            |   |__nuclear polyadenylation-dependent mRNA catabolic process
                                                            |__polyuridylation-dependent mRNA catabolic process 2 rec.
                                                            |   |__polyuridylation-dependent decapping of nuclear-transcribed mRNA
                                                            |__siRNA-mediated gene silencing by mRNA destabilization 1 rec.
                                                            |   |__siRNA-mediated long-distance post-transcriptional gene silencing
                                                            |__transposable element silencing by mRNA destabilization 10 rec.
                                                                |__transposable element silencing by piRNA-mediated mRNA destabilization 8 rec.
                                                                |__transposable element silencing by siRNA-mediated mRNA destabilization
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Is a negative regulation of gene expression
regulation of mRNA stability
RNA destabilization
positive regulation of mRNA catabolic process
Part of
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