FB2026_03 , released September 17, 2026
CV Term Report
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Term siRNA-mediated gene silencing by mRNA destabilization ID (Ontology) GO:0090625 (Gene Ontology)
Definition An siRNA-mediated post-transcriptional gene silencing pathway in which small interfering RNAs (siRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), an siRNA will typically direct cleavage by base pairing with perfect or near-perfect complementarity to the target mRNA.[ PubMed:15260970 ]
Also Known As"mRNA cleavage involved in gene silencing by siRNA" ; "mRNA destabilization-mediated gene silencing by siRNA"
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Genes (FBgn)GO_BIOLOGICAL_PROCESS
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 siRNA-mediated gene silencing by mRNA destabilization (all annotations which use CV term, excluding "NOT" statements)
     involved_in | siRNA-mediated gene silencing by mRNA destabilization
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negative regulation of gene expression
 |__mRNA destabilization_______________________________________
regulatory ncRNA-mediated post-transcriptional gene silencing  |
 |__siRNA-mediated post-transcriptional gene silencing_________|
regulation of mRNA stability                                   |
 |__mRNA destabilization_______________________________________|
RNA destabilization                                            |
 |__mRNA destabilization_______________________________________|
positive regulation of mRNA catabolic process                  |
 |__mRNA destabilization_______________________________________|
                                                               siRNA-mediated gene silencing by mRNA destabilization  1 rec.
                                                                |__siRNA-mediated long-distance post-transcriptional gene silencing
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Is a mRNA destabilization
siRNA-mediated post-transcriptional gene silencing
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Synonyms
  • "gene silencing by mRNA cleavage" BROAD
    "mRNA cleavage involved in gene silencing by siRNA" EXACT
    "mRNA destabilization-mediated gene silencing by siRNA" EXACT
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