FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term general transcription initiation factor activity ID (Ontology) GO:0140223 (Gene Ontology)
Definition A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary.
Also Known As "basal transcription factor activity" ; "general transcription factor activity" ; "GTF activity"
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    Gene Groups: 6
    Genes: 35
    Results list data from multiple species. Annotation result lists are temporarily unavailable.
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       3
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 Genes
 general transcription initiation factor activity (all annotations which use CV term, excluding "NOT" statements)       3
     enables | general transcription initiation factor activity       3
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  molecular_function
   |__general transcription initiation factor activity  41 rec.
       |__mitochondrial RNA polymerase general transcription initiation factor activity
       |__RNA polymerase I general transcription initiation factor activity 1 rec.
       |__RNA polymerase II general transcription initiation factor activity 35 rec.
       |__RNA polymerase III general transcription initiation factor activity 6 rec.
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Synonyms
  • "basal transcription factor activity" EXACT
    "general transcription factor activity" EXACT
    "GTF activity" EXACT
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