FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

general transcription initiation factor activity

ID (Ontology)

GO:0140223 (Gene Ontology)

Definition

A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary.

Also Known As

"basal transcription factor activity" ; "general transcription factor activity" ; "GTF activity"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

Choose a record type to view annotations for this term and its child terms. Direct annotations and full annotation statements below also provide HitList buttons.

Results list data from multiple species. Choose a record type above to open its HitList.

Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_MOLECULAR_FUNCTION

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
general transcription initiation factor activity (all annotations which use CV term, excluding "NOT" statements)
enables \| general transcription initiation factor activity

Spanning Tree (Parents/Children)

  molecular_function
   |__general transcription initiation factor activity  43 rec.
       |__mitochondrial RNA polymerase general transcription initiation factor activity
       |__RNA polymerase I general transcription initiation factor activity 1 rec.
       |__RNA polymerase II general transcription initiation factor activity 37 rec.
       |__RNA polymerase III general transcription initiation factor activity 6 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	molecular_function
Part of
Synonyms & Secondary IDs
Synonyms
	"basal transcription factor activity" EXACT "general transcription factor activity" EXACT "GTF activity" EXACT
Secondary IDs

External Crossreferences & Linkouts