FB2026_03 , released September 17, 2026

CV Term Report

Help Close All Open All

General Information

Term

protein-containing complex destabilizing activity

ID (Ontology)

GO:0140776 (Gene Ontology)

Definition

A molecular function that involves direct binding to one of the subunits of a protein-containing complex and promoting the dissociation of one or many subunits. This often happens by changing the conformation of the protein being bound, which decreases its affinity for the rest of the complex.[ PubMed:23727094 PubMed:29779865 PubMed:34836783 ]

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

Choose a record type to view annotations for this term and its child terms. Direct annotations and full annotation statements below also provide HitList buttons.

Results list data from multiple species. Choose a record type above to open its HitList.

Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_MOLECULAR_FUNCTION

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
protein-containing complex destabilizing activity (all annotations which use CV term, excluding "NOT" statements)
enables \| protein-containing complex destabilizing activity

Spanning Tree (Parents/Children)

  molecular_function
   |__protein-containing complex destabilizing activity  8 rec.
       |__actin filament debranching activity
       |__actin filament severing activity
       |__ATP-dependent protein disaggregase activity 1 rec.
       |__microtubule destabilizing activity 6 rec.
           |__microtubule severing ATPase activity 6 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	molecular_function
Part of
Synonyms & Secondary IDs
Synonyms
	"protein unfoldase activity" BROAD
Secondary IDs

External Crossreferences & Linkouts