FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term pore-forming activity ID (Ontology) GO:0140911 (Gene Ontology)
Definition An activity in which a protein is inserted into the membrane of another cell where it forms transmembrane pores. Pores disrupts the integrity of the cell membrane, resulting in deregulated ion homeostasis, cellular dysfunction, and can result in cell death.[ PubMed:1406491 PubMed:25157079 PubMed:34387717 ]
Also Known As"pore forming activity"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 pore-forming activity (all annotations which use CV term, excluding "NOT" statements)
     enables | pore-forming activity
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  molecular_function
   |__pore-forming activity  1 rec.
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Synonyms
  • "canonical holin activity" NARROW
    "holin activity" NARROW
    "pinholin activity" NARROW
    "pore forming activity" EXACT
Secondary IDs
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TC:1.C