interaction detection method
   |__interaction prediction
       |__sequence based prediction  5 rec.
           |__correlated mutations
           |__domain fusion
           |__domain profile pairs
           |__interologs mapping 2 rec.
           |__sequence based phylogenetic profile
           |   |__phylogenetic profiling of predicted gene regulatory region binding sites
           |__sequence based prediction of binding of transcription factor to transcribed gene regulatory elements
           |__sequence based prediction of gene regulatory region binding sites
               |__phylogenetic profiling of predicted gene regulatory region binding sites