FB2025_01 , released February 20, 2025
Allele: Dmel\GstS104227
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General Information
Symbol
Dmel\GstS104227
Species
D. melanogaster
Name
FlyBase ID
FBal0008054
Feature type
allele
Associated gene
Dmel\GstS1
Associated Insertion(s)
P{PZ}GstS104227
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
Progenitor genotype
Associated Insertion(s)
P{PZ}GstS104227
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{PZ}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  Parkinson's disease
      modeled by park25
      (Whitworth et al., 2005)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      GstS104227 mutants have no effect on climbing ability.

      (Whitworth et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      GstS1[+]/GstS104227 is an enhancer of abnormal locomotor behavior | adult stage phenotype of park25

      (Whitworth et al., 2005)

      GstS104227 is an enhancer of visible | dominant phenotype of KrIf-1

      (Abrell et al., 2000)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      GstS104227 is an enhancer of eye phenotype of KrIf-1

      (Abrell et al., 2000)

      GstS104227 is an enhancer of ommatidium phenotype of KrIf-1

      (Abrell et al., 2000)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The homozygous park25 mutant climbing defect is enhanced when heterozygous with GstS104227. GstS104227 mutants have no effect on climbing ability in heterozygous park25 mutants.

      (Whitworth et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      A. Spradling.

      Comments
      Comments

      This allele was listed in the BDGP database as a lethal or sterile line during the period 1994-1999, but was discarded from the gene disruption project prior to the summary publication (FBrf0111489). Reasons for excluding lines from the collection described in FBrf0111489 include presence of more than one P insertion on the mutant chromosome, separation of lethality (or sterility) from the location of the insertion, and loss of lethality (or sterility) from the stock. Further information is available from http://www.fruitfly.org/bfd/ and from Dr. Spradling (spradling@mail1.ciwemb.edu).

      Complements: RhoGEF204291. Complements: Sply05091. Complements: l(2)0625306253. Complements: GstS1k08805. Complements: l(2)k09303k09303. Complements: l(2)k09854k09854. Complements: l(2)k11301k11301. Complements: l(2)k11405k11405.

      (BDGP Project Members, 1994-1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      Gst204227
      (BDGP Project Members, 1994-1999)
      GstS104227
      GstS14227
      (Whitworth et al., 2005)
      l(2)04227
      (Abrell et al., 2000)
      l(2)0422704227
      Name Synonyms
      Secondary FlyBase IDs
        References (4)