FB2025_01 , released February 20, 2025
Allele: Dmel\ninaE5
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General Information
Symbol
Dmel\ninaE5
Species
D. melanogaster
Name
FlyBase ID
FBal0013010
Feature type
allele
Associated gene
Dmel\ninaE
Associated Insertion(s)
Carried in Construct
Also Known As
ninaEP318
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Kumar and Ready, 1995)
Mutagen
ethyl methanesulfonate
Progenitor genotype
Cytology
Description

Amino acid replacement: P120L.

(Mitra et al., 2011, Kumar and Ready, 1995, Kurada and O'Tousa, 1995)

normal transcript level; Pro120 --> Leu

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:19,887,609..19,887,609 [-]
Nucleotide change:

C19887609T

Amino acid change:

P120L | ninaE-PA

Reported amino acid change:

P120L|FBrf0080181

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Kumar and Ready, 1995, Kurada and O'Tousa, 1995)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant larvae show defects in discrimination between 18[o]C and 24[o]C in a binary choice thermotaxis assay compared to controls, but discrimination between 18[o]C and cooler or very warm temperatures is normal.

      (Shen et al., 2011)

      The shape and integrity of the rhabdomeres remains intact in 7 day old mutant flies, although each peripheral rhabdomere appears smaller than normal.

      (Ni et al., 2008)

      Individuals develop reasonably normal rhabdomeres and none show membrane curtains.

      (Kumar and Ready, 1995)

      Third instar foraging larvae show negative photobehaviour indistinguishable from the wild-type response to light. Third instar larvae continue to show negative phototaxis during the wandering stage, in contrast to wild-type larvae.

      (Sawin-McCormack et al., 1995)

      Displays locomotor activity rhythm with an approximately 24h period.

      (Vosshall and Young, 1995)

      Slow rate of degeneration of R1-6 photoreceptors.

      (Leonard et al., 1992)

      ERG phenotype: light coincident response is large, transients are present.

      (O'Tousa et al., 1989)

      Homozygotes have very little rhodopsin, heterozygotes have approximately 51% rhodopsin compared to wild-type levels.

      (Scavarda et al., 1983)

      3-13% normal RH1 level

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The average size of the peripheral rhabdomeres in 7 day old tadr1 ; ninaE5 flies is significantly larger than in tadr1 single mutants and is the same as in ninaE5 single mutants.

      (Ni et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (3)
      Notes on Origin
      Discoverer

      Pak.

      Comments
      Comments

      Encodes 1.5% of wild type levels of R1-6 rhodopsin (Johnson and Pak, J. Gen Physiol. 88:651--673 ).

      (Leonard et al., 1992)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      References (17)