FB2025_01 , released February 20, 2025
Allele: Dmel\trh8
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General Information
Symbol
Dmel\trh8
Species
D. melanogaster
Name
FlyBase ID
FBal0050667
Feature type
allele
Associated gene
Dmel\trh
Associated Insertion(s)
P{PZ-Δ8}trh8
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Chung et al., 2011)
Mutagen
P-element activity
(Isaac and Andrew, 1996)
Progenitor genotype
P{PZ}trh10512
(Chung et al., 2011)
trh10512
(Isaac and Andrew, 1996)
Associated Insertion(s)
P{PZ-Δ8}trh8
Cytology
Description

8949bp internal deletion of the progenitor P{PZ}trh10512 insertion (nucleotides 2740-11687 deleted), leaving the flanking genomic region intact.

(Chung et al., 2011)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      trh8 homozygous embryos lack trachea while they do not exhibit any changes in gonad niche morphology when compared to controls.

      (Anllo et al., 2019)

      Spiracular chamber cells still invaginate, forming a filzkorper. The filzkorper is shorter than wild type.

      (Hu and Castelli-Gair, 1999)

      In homozygous embryos the Malpighian tubules join a common ureter and are wider than normal. Cell rearrangement is not completed in the tubules.

      (Jack and Myette, 1999)

      The filzkorper do not elongate and trachea do not form properly. The oesophagus, gastric caecae and Malpighian tubules are unaffected.

      (Isaac and Andrew, 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      trh8 tgo1 double mutants completely lack tracheal staining.

      (Sonnenfeld et al., 1997)
      Xenogenetic Interactions
      Statement
      Reference

      The vvl expressing cells seen when Ecol\lacZvvl.1+2 is expressed in embryos in a trh8 mutant background fail to invaginate, remaining on the epidermal surface of the embryo.

      The vvl expressing cells seen when Ecol\lacZvvl.345 is expressed in embryos in a trh8 mutant background fail to invaginate, remaining on the epidermal surface of the embryo.

      (Sotillos et al., 2010)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      trh alleles fall into an allelic series. From strongest to weakest: trh1 = trh8 > trh7 > trh10512 > trh6 > trh5 > trh4.

      (Isaac and Andrew, 1996)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      References (12)