FB2025_01 , released February 20, 2025
Allele: Dmel\Polr2BS6
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General Information
Symbol
Dmel\Polr2BS6
Species
D. melanogaster
Name
FlyBase ID
FBal0091647
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Nature of the Allele
Allele class
Progenitor genotype
Cytology
Description

Mutant lesions in RpII140S1, RpII140S2, RpII140S5, RpII140S6 and RpII140S8 are identical. Nucleotide substitution: A2966T.

Amino acid replacement: S728C. Nucleotide substitution: A2966T.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Nucleotide change:

A14128255T

Reported nucleotide change:
Amino acid change:

S728C | Polr2B-PA; S728C | Polr2B-PB

Reported amino acid change:
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference

Polr2BS6 is a suppressor of lethal phenotype of Polr2AK1

NOT Suppressor of
Statement
Reference

Polr2BS6 is a non-suppressor of lethal phenotype of Polr2A1

Polr2BS6 is a non-suppressor of lethal phenotype of Polr2A106

Polr2BS6 is a non-suppressor of lethal phenotype of Polr2A108

Polr2BS6 is a non-suppressor of lethal phenotype of Polr2A109

Polr2BS6 is a non-suppressor of lethal phenotype of Polr2A12

Polr2BS6 is a non-suppressor of lethal phenotype of Polr2A66

Polr2BS6 is a non-suppressor of lethal phenotype of Polr2AUbl

Polr2BS6 is a non-suppressor of lethal phenotype of Polr2Ats

Phenotype Manifest In
Suppressor of
Statement
Reference

Polr2BS6 is a suppressor of phenotype of Polr2AK1

Additional Comments
Genetic Interactions
Statement
Reference

The recessive lethality of RpII2151, RpII215Ubl, RpII215ts, RpII21566, RpII215106, RpII215108, RpII21512 or RpII215109 is not rescued by one copy of RpII140S6. The recessive lethality of RpII215K1 is rescued to more than 50% viability by one copy of RpII140S6.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Polr2BS6
RpII140S6
Name Synonyms
Secondary FlyBase IDs
    References (2)