FlyBase Allele Report: Dmel\EloC[SH1520]

General Information

Symbol

Dmel\EloC^SH1520

Species

D. melanogaster

Name

FlyBase ID

FBal0143659

Feature type

allele

Associated gene

Dmel\EloC

Associated Insertion(s)

P{lacW}EloC^SH1520

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - molecular evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - molecular evidence

(Rougeot et al., 2013)

Mutagen

P-element activity

(Oh et al., 2003)

Progenitor genotype

Associated Insertion(s)

P{lacW}EloC^SH1520

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:19,446,289..19,446,323

(Rougeot et al., 2013, Oh et al., 2003)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with EloC^SH1299)

(Rougeot et al., 2013)

lethal | recessive

(Oh et al., 2003)

lethal - all die before end of second instar larval stage

(Rougeot et al., 2013)

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygotes die before the third larval instar stage. Rare EloC^SH1299/EloC^SH1520 third instar larvae die before pupariation.

1.4% of heterozygous females have a truncated L5 wing vein.

(Rougeot et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

EloC^SH1520/l(2)SH1520[+] is a suppressor | partially of visible | dominant phenotype of corto^07128b

(Rougeot et al., 2013)

EloC^SH1520/l(2)SH1520[+] is a suppressor of visible | dominant phenotype of trx^E2

(Rougeot et al., 2013)

EloC^SH1520/l(2)SH1520[+] is a suppressor of visible | dominant phenotype of corto^l1

(Rougeot et al., 2013)

EloC^SH1520/l(2)SH1520[+] is a suppressor | partially of visible | dominant phenotype of bs^EY23316

(Rougeot et al., 2013)

EloC^SH1520/l(2)SH1520[+] is a suppressor of visible | dominant phenotype of kis¹

(Rougeot et al., 2013)

EloC^SH1520/l(2)SH1520[+] is a suppressor of visible | dominant phenotype of mor¹

(Rougeot et al., 2013)

Phenotype Manifest In

Suppressor of

Statement

Reference

EloC^SH1520/l(2)SH1520[+] is a suppressor | partially of wing vein | ectopic phenotype of corto^07128b

(Rougeot et al., 2013)

EloC^SH1520/l(2)SH1520[+] is a suppressor of wing vein | ectopic phenotype of trx^E2

(Rougeot et al., 2013)

EloC^SH1520/l(2)SH1520[+] is a suppressor of wing vein | ectopic phenotype of corto^l1

(Rougeot et al., 2013)

EloC^SH1520/l(2)SH1520[+] is a suppressor | partially of wing vein | ectopic phenotype of bs^EY23316

(Rougeot et al., 2013)

EloC^SH1520/l(2)SH1520[+] is a suppressor of wing vein | ectopic phenotype of kis¹

(Rougeot et al., 2013)

EloC^SH1520/l(2)SH1520[+] is a suppressor of wing vein | ectopic phenotype of mor¹

(Rougeot et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

EloC^SH1520/+ reduces the expressivity of the bs^EY23316/+ ectopic wing vein phenotype.

The penetrance of the ectopic wing vein phenotype seen in corto^07128b/+ females (over 90% penetrance) is reduced if they are also heterozygous for EloC^SH1520 (14.8% penetrance).

The ectopic wing vein phenotype seen in corto^l1/+ females is suppressed if they are also heterozygous for EloC^SH1520.

The penetrance of the ectopic wing vein phenotype seen in mor¹/+ females (22.5% penetrance) is reduced if they are also heterozygous for EloC^SH1520 (1.5% penetrance).

The penetrance of the ectopic wing vein phenotype seen in kis¹/+ females (81.5% penetrance) is reduced if they are also heterozygous for EloC^SH1520 (17.5% penetrance).

The penetrance of the ectopic wing vein phenotype seen in trx^E2/+ females (53.9% penetrance) is reduced if they are also heterozygous for EloC^SH1520 (5.4% penetrance).

(Rougeot et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

EloC^SH1520

(Rougeot et al., 2013)

l(2)SH1520^SH1520

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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