FB2025_01 , released February 20, 2025
Allele: Dmel\EloCSH1299
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General Information
Symbol
Dmel\EloCSH1299
Species
D. melanogaster
Name
FlyBase ID
FBal0160497
Feature type
allele
Associated gene
Dmel\EloC
Associated Insertion(s)
P{lacW}EloCSH1299
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - molecular evidence

    (Rougeot et al., 2013)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{lacW}EloCSH1299
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    P{lacW}
    Encoded product / tool
    lacZ
    Tagged with
    Tag:NLS(P)
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
    BZ592570
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Homozygotes die during the third larval instar stage. Rare EloCSH1299/EloCSH1520 third instar larvae die before pupariation.

        (Rougeot et al., 2013)

        Mosaic animals in which the eyes are homozygous for Elongin-CSH1299 in an otherwise heterozygous background have a normal electroretinogram.

        (Wang et al., 2008)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressor of
        Statement
        Reference

        Elongin-C[+]/EloCSH1299 is a suppressor | partially of visible | dominant phenotype of corto07128b

        (Rougeot et al., 2013)

        Elongin-C[+]/EloCSH1299 is a suppressor of visible | dominant phenotype of trxE2

        (Rougeot et al., 2013)

        Elongin-C[+]/EloCSH1299 is a suppressor of visible | dominant phenotype of cortol1

        (Rougeot et al., 2013)

        Elongin-C[+]/EloCSH1299 is a suppressor | partially of visible | dominant phenotype of bsEY23316

        (Rougeot et al., 2013)

        Elongin-C[+]/EloCSH1299 is a suppressor of visible | dominant phenotype of kis1

        (Rougeot et al., 2013)

        Elongin-C[+]/EloCSH1299 is a suppressor of visible | dominant phenotype of mor1

        (Rougeot et al., 2013)
        Phenotype Manifest In
        Suppressor of
        Statement
        Reference

        Elongin-C[+]/EloCSH1299 is a suppressor | partially of wing vein | ectopic phenotype of corto07128b

        (Rougeot et al., 2013)

        Elongin-C[+]/EloCSH1299 is a suppressor of wing vein | ectopic phenotype of trxE2

        (Rougeot et al., 2013)

        Elongin-C[+]/EloCSH1299 is a suppressor of wing vein | ectopic phenotype of cortol1

        (Rougeot et al., 2013)

        Elongin-C[+]/EloCSH1299 is a suppressor | partially of wing vein | ectopic phenotype of bsEY23316

        (Rougeot et al., 2013)

        Elongin-C[+]/EloCSH1299 is a suppressor of wing vein | ectopic phenotype of kis1

        (Rougeot et al., 2013)

        Elongin-C[+]/EloCSH1299 is a suppressor of wing vein | ectopic phenotype of mor1

        (Rougeot et al., 2013)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        EloCSH1299/+ reduces the penetrance and expressivity of the bsEY23316/+ ectopic wing vein phenotype.

        The penetrance of the ectopic wing vein phenotype seen in corto07128b/+ females (over 90% penetrance) is reduced if they are also heterozygous for EloCSH1299 (27.5% penetrance).

        The ectopic wing vein phenotype seen in cortol1/+ females is suppressed if they are also heterozygous for EloCSH1299.

        The penetrance of the ectopic wing vein phenotype seen in mor1/+ females (22.5% penetrance) is reduced if they are also heterozygous for EloCSH1299 (6.4% penetrance).

        The penetrance of the ectopic wing vein phenotype seen in kis1/+ females (81.5% penetrance) is reduced if they are also heterozygous for EloCSH1299 (9.2% penetrance).

        The penetrance of the ectopic wing vein phenotype seen in trxE2/+ females (53.9% penetrance) is reduced if they are also heterozygous for EloCSH1299 (16.7% penetrance).

        (Rougeot et al., 2013)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 1 )
        Crossreferences
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        EloCSH1299
        (Rougeot et al., 2013)
        Elongin-CSH1299
        Name Synonyms
        Secondary FlyBase IDs
          References (3)