Allele Dmel\Sox15^KG09145

General Information
Symbol	Dmel\Sox15^KG09145	Species	D. melanogaster
Name		FlyBase ID	FBal0147414
Feature type	allele	Associated gene	Dmel\Sox15

Map ( GBrowse )	Untitled Document
Allele class	amorphic allele - genetic evidence
Mutagen	P-element activity
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	amorphic allele - genetic evidence (Dichtel-Danjoy et al., 2009)
Mutagen	P-element activity (Gene Disruption Project members, 2001-)
Mutations Mapped to the Genome

Type Location Additional Notes References transposable element insertion site 2R:10,096,285..10,096,285 (Gene Disruption Project members, 2001-, Miller et al., 2009, Dichtel-Danjoy et al., 2009)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Insertion within the first intron. (Miller et al., 2009)
Caused by insertion	P{SUPor-P}Sox15^KG09145 (Gene Disruption Project members, 2001-, Miller et al., 2009, Dichtel-Danjoy et al., 2009)
Cytology
Phenotypic Data
Phenotypic Class
	increased cell death \| recessive \| third instar larval stage (Dichtel-Danjoy et al., 2009) increased cell number \| recessive \| third instar larval stage (Dichtel-Danjoy et al., 2009) partially lethal - majority die \| recessive (Dichtel-Danjoy et al., 2009) size defective \| recessive \| third instar larval stage (Dichtel-Danjoy et al., 2009)
Phenotype Manifest In
	alula (Dichtel-Danjoy et al., 2009) wing hinge (Dichtel-Danjoy et al., 2009) wing hinge primordium (Dichtel-Danjoy et al., 2009) wing sclerite (Dichtel-Danjoy et al., 2009)
Detailed Description
	Statement Reference Most homozygous Sox15[KG09145] flies die as pharate adults. The homozygous Sox15[KG09145] escapers are weak and display held-out wings. The held-out-wing phenotype is the result of abnormalities in proximal hinge structures, such as the sclerites, the alula and the costa. Sox15[KG09145] mutant third instar larval wing imaginal discs show hinge overgrowth that causes extra folds both dorsally and ventrally. There is an increase in cell proliferation in the hinge region of Sox15[KG09145] mutant L3 wing imaginal discs relative to the wild-type. The rate of apoptotic cell death is also increased in Sox15[KG09145] mutant wing discs in the hinge region. The wing pouch and body wall regions appear unaffected in Sox15[KG09145] mutant third instar larval wing imaginal discs. (Dichtel-Danjoy et al., 2009)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference Sox15^KG09145 has increased cell number \| recessive \| third instar larval stage phenotype, suppressible by wg^spd-fg (Dichtel-Danjoy et al., 2009)
Enhancer of
Statement Reference Sox15^KG09145 is an enhancer of decreased cell number \| recessive \| third instar larval stage phenotype of wg^spd-fg (Dichtel-Danjoy et al., 2009) Sox15^KG09145 is an enhancer of size defective \| recessive \| third instar larval stage phenotype of wg^spd-fg (Dichtel-Danjoy et al., 2009)
Other
Statement Reference Sox15^KG09145, wg^spd-fg has size defective \| recessive \| third instar larval stage phenotype (Dichtel-Danjoy et al., 2009)
Phenotype Manifest In
Enhancer of
Statement Reference Sox15^KG09145 is an enhancer of wing hinge primordium phenotype of wg^spd-fg (Dichtel-Danjoy et al., 2009)
Other
Statement Reference Sox15^KG09145, wg^spd-fg has wing hinge primordium phenotype (Dichtel-Danjoy et al., 2009)
Additional Comments
Genetic Interactions
Statement Reference In wg[spd-fg], Sox15[KG09145] double mutant third instar larval wing imaginal discs, the distal hinge region is reduced in size compared to either single mutant. The rate of hinge-specific apoptosis is similar in wg[spd-fg], Sox15[KG09145] double mutant and Sox15[KG09145] single mutant L3 wing discs. (Dichtel-Danjoy et al., 2009)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 2 )
Bloomington	14980 y¹; P{SUPor-P}Sox15^KG09145/CyO; ry⁵⁰⁶
Kyoto	114403 y^d2 w¹¹¹⁸ P{ey-FLP.N}2; P{neoFRT}42D P{SUPor-P}Sox15^KG09145 /CyO y⁺
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Sox15^KG09145 (Christensen et al., 2007.10.29, Dichtel-Danjoy et al., 2009) SoxF^KG09145 (Dichtel-Danjoy et al., 2009)
Name Synonym
Secondary FlyBase IDs

References ( 5 )
Research paper	Dichtel-Danjoy et al., 2009, Development 136(5): 761--769 SoxF is part of a novel negative-feedback loop in the wingless pathway that controls proliferation in the Drosophila wing disc. [FBrf0206770] Miller et al., 2009, Dev. Biol. 329(2): 386--399 Complex interplay of three transcription factors in controlling the tormogen differentiation program of Drosophila mechanoreceptors. [FBrf0207969]
Personal communication to FlyBase	Christensen et al., 2007.10.29, Isolation and characterization of Df(3L)BSC401. Isolation and characterization of Df(3L)BSC401. [FBrf0200257] Christensen and Cook, 2006.3.8, Isolation and characterization of Df(2R)BSC134. Isolation and characterization of Df(2R)BSC134. [FBrf0191669] Gene Disruption Project members, 2001-, (Computer file) (Computer file) [FBrf0132177]

Allele Dmel\Sox15KG09145

Allele Dmel\Sox15^KG09145