Allele Dmel\eve^ΔRP2A

General Information
Symbol	Dmel\eve^ΔRP2A	Species	D. melanogaster
Name		FlyBase ID	FBal0155322
Feature type	allele	Associated gene	Dmel\eve

Allele class
Mutagen	in vitro construct - deletion
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	in vitro construct - deletion (Fujioka et al., 2003)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	eve^E+L.9.2 (Fujioka et al., 2003)
Nature of the lesion	Statement Reference Construct: The last 1kb of sequence (+8.2 to +9.2kb) of the eve^E+L.9.2 genomic region has been deleted. (Fujioka et al., 2003)
Carried in construct	P{eve.ΔRP2A} (Garces and Thor, 2006, Fujioka et al., 2003)
Cytology
Phenotypic Data
Phenotypic Class
	neuroanatomy defective (Garces and Thor, 2006)
Phenotype Manifest In
	aCC neuron (Garces and Thor, 2006) RP2 motor neuron (Garces and Thor, 2006) RP2 motor neuron, with eve^unspecified (Fujioka et al., 2003)
Detailed Description
	Statement Reference eve[ΔRP2A] mutants exhibit a failure of aCC/RP2 motoneurons to project out of the ventral nerve cord. In aCC, these effects are highly penetrant and observed at several stages, whereas in RP2 the effects are partially penetrant at stage 12 and almost absent at stage 15. (Garces and Thor, 2006)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT suppressed by
Statement Reference eve^ΔRP2A has neuroanatomy defective phenotype, non-suppressible by Scer\GAL4^eve.RN2/grn^Scer\UAS.cBa (Garces and Thor, 2006)
Other
Statement Reference Df(2R)eve, eve^ΔRP2A, unc-5⁸ has neuroanatomy defective phenotype (Zarin et al., 2012)
Phenotype Manifest In
NOT suppressed by
Statement Reference eve^ΔRP2A has aCC neuron phenotype, non-suppressible by Scer\GAL4^eve.RN2/grn^Scer\UAS.cBa (Garces and Thor, 2006)
Other
Statement Reference Df(2R)eve, eve^ΔRP2A, unc-5⁸ has intersegmental nerve phenotype (Zarin et al., 2012)
Additional Comments
Genetic Interactions
Statement Reference eve[ΔRP2A], Df(2R)eve/+ ; unc-5[8]/+ double heterozygous embryos show guidance defects in the intersegmental nerve. (Zarin et al., 2012) Expression of grn[Scer\UAS.cBa] in the aCC/RP2 neurons, under the control of Scer\GAL4[eve.RN2] does not rescue the failure of aCC to project its axon out of the ventral nerve cord in eve[ΔRP2A] mutants. (Garces and Thor, 2006)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescues	eve^ΔRP2A rescues eve^unspecified (Fujioka et al., 2003)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	Df(2R)eveΔRP2A (Lacin et al., 2009) eve^ΔRP2 (Zarin et al., 2012) eve^ΔRP2A RP2A (Zarin et al., 2012)
Name Synonym
Secondary FlyBase IDs

References ( 4 )
Research paper	Zarin et al., 2012, Development 139(10): 1798--1805 A GATA/homeodomain transcriptional code regulates axon guidance through the Unc-5 receptor. [FBrf0218039] Lacin et al., 2009, Development 136(19): 3257--3266 dbx mediates neuronal specification and differentiation through cross-repressive, lineage-specific interactions with eve and hb9. [FBrf0210354] Garces and Thor, 2006, Development 133(8): 1445--1455 Specification of Drosophila aCC motoneuron identity by a genetic cascade involving even-skipped, grain and zfh1. [FBrf0190291] Fujioka et al., 2003, Development 130(22): 5385--5400 Even-skipped, acting as a repressor, regulates axonal projections in Drosophila. [FBrf0167497]

Allele Dmel\eveΔRP2A

Allele Dmel\eve^ΔRP2A