FlyBase Allele Report: Dmel\Rcc1[FF32]

General Information

Symbol

Dmel\Rcc1^FF32

Species

D. melanogaster

Name

FlyBase ID

FBal0157267

Feature type

allele

Associated gene

Dmel\Rcc1

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Shi and Skeath, 2004)

Mutagen

ethyl methanesulfonate

(Shi and Skeath, 2004)

Progenitor genotype

Cytology

Description

Contains a 15bp deletion from base 769 to 783 of the Bj1 gene, which results in a 5 aa in-frame deletion at the beginning of the second RCC1 repeat.

(Shi and Skeath, 2004)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3L:5,931,991..5,932,005 [-]

Comment:

15 base in-frame deletion at the beginning of the second RCC1 repeat.

(Shi and Skeath, 2004)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

central nervous system | lateral

(Shi and Skeath, 2004)

central nervous system | lateral (with Df(3L)ZN47)

(Shi and Skeath, 2004)

eye

(Shi and Skeath, 2004)

eye photoreceptor cell

(Shi and Skeath, 2004)

larval EL neuron

(Shi and Skeath, 2004)

larval EL neuron (with Df(3L)ZN47)

(Shi and Skeath, 2004)

ommatidium

(Shi and Skeath, 2004)

Detailed Description

Statement

Reference

Homozygous mutant embryos exhibit an approximately 50% reduction of EL neurons with 3-5 ELs developing per abdominal hemisegment. These mutant embryos also exhibit morphological defects in the lateral CNS as the lateral margin of mutant nerve cords appear rough and scalloped relative to wild-type. When Bj1^FF32 mutant eyes are created, they are greatly reduced in size and the majority of photoreceptors fail to develop - though a few disorganised ommatidia still form.

(Shi and Skeath, 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressor of

Statement

Reference

Rcc1^FF32 is a suppressor of ommatidium phenotype of hid^GMR.PG

(Shi and Skeath, 2004)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Rcc1^EP3630

(Shi and Skeath, 2004)

Rescued by

Rcc1^FF32 is rescued by Rcc1^{del.UAS.Tag:MYC}/Scer\GAL4^sca-109-68

(Shi and Skeath, 2004)

Rcc1^FF32 is rescued by Scer\GAL4^sca-109-68/Rcc1^UAS.cSa

(Shi and Skeath, 2004)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

37720

Rcc1^FF32 hry¹ Diap1^th-1 st¹ cu¹ sr¹ e^s/TM3, P{ftz-lacZ.ry⁺}TM3, Sb¹ ry^*

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Bj1^FF32

RCC1^FF32

(Bivik et al., 2015)

Rcc1^FF32

dRCC1^FF32

(Shi and Skeath, 2004)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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