FlyBase Allele Report: Dmel\jeb[weli]

General Information

Symbol

Dmel\jeb^weli

Species

D. melanogaster

Name

welville

FlyBase ID

FBal0159133

Feature type

allele

Associated gene

Dmel\jeb

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Stute et al., 2004)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates neurofibromatosis

modeled by Nf1^E2

(Walker et al., 2013)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

circular trunk visceral muscle primordium

(Wolfstetter et al., 2009)

fusion competent cell & visceral muscle primordium

(Stute et al., 2004)

gonadal sheath proper primordium | embryonic stage 13 (with Df(2R)BSC699)

(Anllo and DiNardo, 2022)

muscle founder cell & circular visceral muscle primordium

(Stute et al., 2004)

visceral trunk mesoderm | embryonic stage 13 (with Df(2R)BSC699)

(Anllo and DiNardo, 2022)

visceral trunk mesoderm | embryonic stage (with Df(2R)BSC199)

(Hugosson et al., 2014)

Detailed Description

Statement

Reference

Unlike controls, jeb^weli/Df(2R)BSC699 stage 13 embryos do not show intermingling between visceral mesoderm precursor cells and gonadal precursor cells.

(Anllo and DiNardo, 2022)

The visceral mesoderm fails to undergo fusion in jeb^weli/Df(2R)BSC199 embryos and is abnormal.

(Hugosson et al., 2014)

Mutant embryos lack all circular visceral founder cells, but show normal early endoderm migration.

(Wolfstetter et al., 2009)

Morphological and marker analyses indicate that stage 11 jeb^weli homozygous embryos lack muscle founder cells in their circular visceral mesoderm. The remaining cells in the visceral mesoderm differentiate as fusion competent myoblasts and express genes that are characteristic for this differentiated cell type.

(Stute et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

jeb^weli/jeb[+] is a suppressor of decreased body size | pupal stage phenotype of Nf1^E2

(Walker et al., 2013)

jeb^weli/jeb[+] is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Nf1^E2

(Walker et al., 2013)

Other

Statement

Reference

Alk^Y1355S, jeb^weli has lethal phenotype

(Pfeifer et al., 2022)

Alk^F1251L, jeb^weli has lethal phenotype

(Pfeifer et al., 2022)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

jeb^weli/Df(2R)BSC199 has visceral trunk mesoderm | embryonic stage phenotype, non-suppressible by Scer\GAL4^en-e16E/miple1^UAS.cHa

(Hugosson et al., 2014)

jeb^weli/Df(2R)BSC199 has visceral trunk mesoderm | embryonic stage phenotype, non-suppressible by Scer\GAL4^en-e16E/miple2^UAS.Venus

(Hugosson et al., 2014)

Suppressor of

Statement

Reference

jeb^weli/jeb[+] is a suppressor of NMJ bouton | increased number | third instar larval stage phenotype of Nf1^E2

(Walker et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

The increase in mean number of boutons per neuromuscular junction which is seen in Nf1^E2 third instar larvae is dominantly suppressed by jeb^weli.

(Walker et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

jeb^SH0422

(Bazigou et al., 2007)

Rescued by

jeb^weli/Df(2R)BSC199 is rescued by jeb^UAS.cVa/Scer\GAL4^en-e16E

(Hugosson et al., 2014)

Comments

Scer\GAL4^en-e16E-mediated expression of jeb^Scer\UAS.cVa rescues visceral mesoderm formation in jeb^weli/Df(2R)BSC199 embryos.

(Hugosson et al., 2014)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

jeb^weli

(Anllo and DiNardo, 2022, Pfeifer et al., 2022, Mendoza-Garcia et al., 2021, Wolfstetter et al., 2017, Hugosson et al., 2014, Walker et al., 2013, Wolfstetter et al., 2009, Bazigou et al., 2007)

Name Synonyms

jelly bellywelville

(Wolfstetter et al., 2009)

welville

Secondary FlyBase IDs

References (9)

Report Sections

Open Close