FlyBase Allele Report: Dmel\ATPsynCF6[KK108581]

General Information

Symbol

Dmel\ATPsynCF6^KK108581

Species

D. melanogaster

Name

FlyBase ID

FBal0235665

Feature type

allele

Associated gene

Dmel\ATPsynCF6

Associated Insertion(s)

Carried in Construct

P{KK108581}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK108581}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK108581

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage, with Scer\GAL4^Toll-6-D42

(Cagin et al., 2015)

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^VGlut1-OK371

(Cagin et al., 2015)

lethal - all die before end of P-stage, with Scer\GAL4^nSyb.PU

(Cagin et al., 2015)

visible | adult stage, with Scer\GAL4^Toll-6-D42

(Cagin et al., 2015)

Phenotype Manifest In

mitochondrion | adult stage | male, with Scer\GAL4^VP16.bam

(Sawyer et al., 2017)

mitochondrion | third instar larval stage, with Scer\GAL4^VGlut1-OK371

(Cagin et al., 2015)

neuromuscular junction | third instar larval stage, with Scer\GAL4^VGlut1-OK371

(Cagin et al., 2015)

spermatid, with Scer\GAL4^VP16.bam

(Sawyer et al., 2017)

vacuole | adult stage | male, with Scer\GAL4^VP16.bam

(Sawyer et al., 2017)

wing blade, with Scer\GAL4^Toll-6-D42

(Cagin et al., 2015)

Detailed Description

Statement

Reference

Expression of ATPsynCF6^KK108581 under the control of Scer\GAL4^{bam.T:Hsim\VP16} leads to aberrant mitochondrial elongation along with vacuolar inclusions in spermatid cysts.

(Sawyer et al., 2017)

Expression of ATPsynCF6^KK108581 results in reduced climbing ability and wing inflation defects in adults (with the Scer\GAL4^Toll-6-D42 driver), in decreased mitochondrial volume and number at the larval neuromuscular junctions (with the Scer\GAL4^VGlut-OK371 driver) and is pupal lethal when controlled by the Scer\GAL4^nSyb.PU driver.

(Cagin et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

ATPsynCF6^KK108581, Scer\GAL4^Toll-6-D42 has visible | adult stage phenotype, suppressible | partially by sima^HMS00833, Scer\GAL4^Toll-6-D42

(Cagin et al., 2015)

NOT suppressed by

Statement

Reference

ATPsynCF6^KK108581, Scer\GAL4^Toll-6-D42 has abnormal locomotor behavior | adult stage phenotype, non-suppressible by sima^HMS00833, Scer\GAL4^Toll-6-D42

(Cagin et al., 2015)

Phenotype Manifest In

Suppressed by

Statement

Reference

ATPsynCF6^KK108581, Scer\GAL4^Toll-6-D42 has wing blade phenotype, suppressible | partially by sima^HMS00833, Scer\GAL4^Toll-6-D42

(Cagin et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The wing inflation defect characteristic for adult flies expressing ATPsynCF6^KK108581 under the control of Scer\GAL4^Toll-6-D42 is almost fully rescued by co-expression of sima^HMS00833, however the reduced climbing ability of the ATPsynCF6^KK108581 RNAi flies does not recover upon the co-expression.

(Cagin et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v107826

P{KK108581}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

ATPsyn-Cf6^KK108581

ATPsynCF6^KK108581

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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